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http://hdl.handle.net/2445/133320
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DC Field | Value | Language |
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dc.contributor.author | Oriola Santandreu, David | - |
dc.contributor.author | Casademunt i Viader, Jaume | - |
dc.date.accessioned | 2019-05-16T13:36:15Z | - |
dc.date.available | 2019-05-16T13:36:15Z | - |
dc.date.issued | 2013-07-26 | - |
dc.identifier.issn | 0031-9007 | - |
dc.identifier.uri | http://hdl.handle.net/2445/133320 | - |
dc.description.abstract | KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Physical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1103/PhysRevLett.111.048103 | - |
dc.relation.ispartof | Physical Review Letters, 2013, vol. 111, num. 4, p. 048103 | - |
dc.relation.uri | https://doi.org/10.1103/PhysRevLett.111.048103 | - |
dc.rights | (c) American Physical Society, 2013 | - |
dc.source | Articles publicats en revistes (Física de la Matèria Condensada) | - |
dc.subject.classification | Proteïnes quinases | - |
dc.subject.classification | Monòmers | - |
dc.subject.other | Protein kinases | - |
dc.subject.other | Monomers | - |
dc.title | Cooperative force generation of KIF1A Brownian motors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 629651 | - |
dc.date.updated | 2019-05-16T13:36:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
Files in This Item:
File | Description | Size | Format | |
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629651.pdf | 281.46 kB | Adobe PDF | View/Open |
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