Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/133483
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jarius, S. | - |
dc.contributor.author | Paul, F. | - |
dc.contributor.author | Aktas, Orhan | - |
dc.contributor.author | Asgari, Nasrin | - |
dc.contributor.author | Dale, Russell C. | - |
dc.contributor.author | Seze, J. de | - |
dc.contributor.author | Franciotta, Diego | - |
dc.contributor.author | Fujihara, Kazuo | - |
dc.contributor.author | Jacob, Anu | - |
dc.contributor.author | Kim, H. J. | - |
dc.contributor.author | Kleiter, Ingo | - |
dc.contributor.author | Kümpfel, Tania | - |
dc.contributor.author | Levy, Michael | - |
dc.contributor.author | Palace, Jacqueline | - |
dc.contributor.author | Ruprecht, Klemens | - |
dc.contributor.author | Saiz Hinarejos, Albert | - |
dc.contributor.author | Trebst, Corinna | - |
dc.contributor.author | Weinshenker, Brian G. | - |
dc.contributor.author | Wildemann, Brigitte | - |
dc.date.accessioned | 2019-05-20T15:39:37Z | - |
dc.date.available | 2019-05-20T15:39:37Z | - |
dc.date.issued | 2018-05-03 | - |
dc.identifier.issn | 1742-2094 | - |
dc.identifier.uri | http://hdl.handle.net/2445/133483 | - |
dc.description.abstract | Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD). Owing to a substantial overlap in clinicoradiological presentation, MOG-EM was often unwittingly misdiagnosed as MS in the past. Accordingly, increasing numbers of patients with suspected or established MS are currently being tested for MOG-IgG. However, screening of large unselected cohorts for rare biomarkers can significantly reduce the positive predictive value of a test. To lessen the hazard of overdiagnosing MOG-EM, which may lead to inappropriate treatment, more selective criteria for MOG-IgG testing are urgently needed. In this paper, we propose indications for MOG-IgG testing based on expert consensus. In addition, we give a list of conditions atypical for MOG-EM ('red flags') that should prompt physicians to challenge a positive MOG-IgG test result. Finally, we provide recommendations regarding assay methodology, specimen sampling and data interpretation. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12974-018-1144-2 | - |
dc.relation.ispartof | Journal of Neuroinflammation, 2018, vol. 15, num. 1 | - |
dc.relation.uri | https://doi.org/10.1186/s12974-018-1144-2 | - |
dc.rights | cc-by (c) Jarius, S. et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.classification | Esclerosi múltiple | - |
dc.subject.classification | Mielitis | - |
dc.subject.classification | Malalties del sistema nerviós central | - |
dc.subject.other | Diagnosis | - |
dc.subject.other | Multiple sclerosis | - |
dc.subject.other | Myelitis | - |
dc.subject.other | Central nervous system diseases | - |
dc.title | MOG encephalomyelitis: international recommendations on diagnosis and antibody testing | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 682703 | - |
dc.date.updated | 2019-05-20T15:39:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29724224 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
682703.pdf | 445.64 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License