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http://hdl.handle.net/2445/133585
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DC Field | Value | Language |
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dc.contributor.author | Sambola Ayala, Antonia | - |
dc.contributor.author | Mutuberría, Maria | - |
dc.contributor.author | García del Blanco, Bruno | - |
dc.contributor.author | Alonso, Albert | - |
dc.contributor.author | Barrabés, José A. | - |
dc.contributor.author | Alfonso, Fernando | - |
dc.contributor.author | Bueno, Héctor | - |
dc.contributor.author | Cequier Fillat, Àngel R. | - |
dc.contributor.author | Zueco, Javier | - |
dc.contributor.author | Rodríguez-Leor, Oriol | - |
dc.contributor.author | Bosch, Eduard | - |
dc.contributor.author | Tornos, Pilar | - |
dc.contributor.author | García Dorado, David | - |
dc.date.accessioned | 2019-05-21T12:14:05Z | - |
dc.date.available | 2019-05-21T12:14:05Z | - |
dc.date.issued | 2015-12-25 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | http://hdl.handle.net/2445/133585 | - |
dc.description.abstract | Background: the effects of dual antiplatelet therapy (DAPT) and triple therapy (TT: DAPT plus oral anticoagulation) in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) regarding to CHA2DS2-VASc score remain undefined.We compare the effect of TT vs. DAPT in this setting regarding the CHA2DS2-VASc score. Methods and results: in a prospective multicenter registry, 585 patients (75.2% male, 73.2 ± 8.2 years) with AF undergoing PCI were followed up during 1 year. Of them, 157 (26.8%) had a CHA2DS2-VASc=1, and 428 (73.2%) had a CHA2DS2-VASc ≥2. TT was prescribed in 51.6% with CHA2DS2-VASc=1 and in 55.5% with CHA2DS2-VASc ≥ 2. Patients with CHA2DS2-VASc=1 receiving TT had a similar thromboembolism rate to those on DAPT (1.2% vs. 1.3%, P=0.73), but more total (19.5% vs. 6.9%, P=0.01) and a tendency to more major (4.9% vs. 0%, P=0.06) bleeding. However, patients with CHA2DS2-VASc ≥ 2 receiving TT had a lower thromboembolism rate (1.7% vs. 5.3%, P=0.03) and a trend towards more bleeds (21.8% vs. 15.6%, P=0.06), with an excess of major bleeding (8.4% vs. 3.1%, P=0.01). Rates of major adverse cardiac events (MACE) in both CHA2DS2-VASc subgroups were similar, irrespective of treatment. In a Cox multivariate analysis, TT was associated to major bleeding, but not with MACE. Conclusions: in patients with AF and CHA2DS2-VASc=1 undergoing PCI, the use of TT involves a high risk of bleeding without a significant benefit in preventing thromboembolism. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Japanese Circulation Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1253/circj.CJ-15-0923 | - |
dc.relation.ispartof | Circulation Journal, 2015, vol. 80, num. 2, p. 354-362 | - |
dc.relation.uri | https://doi.org/10.1253/circj.CJ-15-0923 | - |
dc.rights | (c) Japanese Circulation Society, 2015 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Anticoagulants (Medicina) | - |
dc.subject.classification | Fibril·lació auricular | - |
dc.subject.classification | Efectes secundaris dels medicaments | - |
dc.subject.classification | Tromboembolisme | - |
dc.subject.classification | Pròtesis valvulars cardíaques | - |
dc.subject.classification | Malalties coronàries | - |
dc.subject.other | Anticoagulants (Medicine) | - |
dc.subject.other | Atrial fibrillation | - |
dc.subject.other | Drug side effects | - |
dc.subject.other | Thromboembolism | - |
dc.subject.other | Heart valve prosthesis | - |
dc.subject.other | Coronary diseases | - |
dc.title | Effects of triple therapy in patients with non-valvular atrial fibrillation undergoing percutaneous coronary intervention regarding thromboembolic risk stratification | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 662832 | - |
dc.date.updated | 2019-05-21T12:14:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26725763 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
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662832.pdf | 1.03 MB | Adobe PDF | View/Open |
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