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dc.contributor.authorEsteve-Pastor, María Asunción-
dc.contributor.authorGarcía-Fernández, Amaya-
dc.contributor.authorMacías, Manuel-
dc.contributor.authorSogorb, Francisco-
dc.contributor.authorValdés, Mariano-
dc.contributor.authorRoldán, Vanesa-
dc.contributor.authorMuñiz, Javier-
dc.contributor.authorBadimón, Lina, 1953--
dc.contributor.authorRoldán, Inmaculada-
dc.contributor.authorBertomeu Martínez, Vicente-
dc.contributor.authorCequier Fillat, Àngel R.-
dc.contributor.authorLip, Gregory Y.H.-
dc.contributor.authorAnguita, Manuel-
dc.contributor.authorMarín, Francisco-
dc.description.abstractBackground: several bleeding risk scores have been validated in patients with atrial fibrillation (AF). The ORBIT score has been recently proposed as a simple score with the best ability to predict major bleeding. The present study aimed to test the hypothesis that the ORBIT score was superior to the HAS-BLED score for predicting major bleeding and death in "real world" anticoagulated AF patients. Methods and results: we analyzed the predictive performance for bleeding and death of 406 AF patients who underwent 571 electrical cardioversion procedures and 1,276 patients with permanent/persistent AF from the FANTASIIA registry. In the cardioversion population, 21 patients had major bleeding events and 26 patients died. The predictive performance for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.77 (95% CI 0.66-0.88) and 0.82 (95% CI 0.77-0.93), respectively; P=0.080). For the FANTASIIA population, 46 patients had major bleeding events and 50 patients died. The predictive performances for major bleeding of HASBLED and ORBIT were not significantly different (c-statistics 0.63 (95% CI 0.56-0.71) and 0.70 (95% CI 0.62-0.77), respectively; P=0.116). For death, the predictive performances of HAS-BLED and ORBIT were not significantly different in both populations. The ORBIT score categorized most patients as "low risk". Conclusions: despite the original claims in its derivation paper, the ORBIT score was not superior to HAS-BLED for predicting major bleeding and death in a "real world" oral anticoagulated AF population. (Circ J 2016; 80:2102 - 2108)-
dc.format.extent7 p.-
dc.publisherJapanese Circulation Society-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofCirculation Journal, 2016, vol. 80, num. 10, p. 2102-2108-
dc.rights(c) Japanese Circulation Society, 2016-
dc.subject.classificationFibril·lació auricular-
dc.subject.classificationEfectes secundaris dels medicaments-
dc.subject.otherAtrial fibrillation-
dc.subject.otherDrug side effects-
dc.titleIs the ORBIT bleeding risk score superior to the HAS-BLED score in anticoagulated atrial fibrillation patients?-
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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