Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/133609
Title: Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons
Author: Rodríguez-Aznar, Eva
Barrallo-Gimeno, Alejandro
Nieto, M. Angela
Keywords: Micro RNAs
Mitosi
Neurones
Fisiologia
Factors de transcripció
Genètica
Metabolisme
MicroRNAs
Mitosis
Neurons
Physiology
Transcription factors
Genetics
Metabolism
Issue Date: 20-Mar-2013
Publisher: The Society for Neuroscience
Abstract: During the development of the nervous system the regulation of cell cycle, differentiation, and survival is tightly interlinked. Newly generated neurons must keep cell cycle components under strict control, as cell cycle re-entry leads to neuronal degeneration and death. However, despite their relevance, the mechanisms controlling this process remain largely unexplored. Here we show that Scratch2 is involved in the control of the cell cycle in neurons in the developing spinal cord of the zebrafish embryo. scratch2 knockdown induces postmitotic neurons to re-enter mitosis. Scratch2 prevents cell cycle re-entry by maintaining high levels of the cycle inhibitor p57 through the downregulation of miR-25. Thus, Scratch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-entry.
Note: Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.4459-12.2013
It is part of: Journal of Neuroscience, 2013, vol. 33, num. 12, p. 5095-5105
URI: http://hdl.handle.net/2445/133609
Related resource: https://doi.org/10.1523/JNEUROSCI.4459-12.2013
ISSN: 0270-6474
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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