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http://hdl.handle.net/2445/133609
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DC Field | Value | Language |
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dc.contributor.author | Rodríguez-Aznar, Eva | - |
dc.contributor.author | Barrallo-Gimeno, Alejandro | - |
dc.contributor.author | Nieto, M. Angela | - |
dc.date.accessioned | 2019-05-21T15:39:39Z | - |
dc.date.available | 2019-05-21T15:39:39Z | - |
dc.date.issued | 2013-03-20 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/2445/133609 | - |
dc.description.abstract | During the development of the nervous system the regulation of cell cycle, differentiation, and survival is tightly interlinked. Newly generated neurons must keep cell cycle components under strict control, as cell cycle re-entry leads to neuronal degeneration and death. However, despite their relevance, the mechanisms controlling this process remain largely unexplored. Here we show that Scratch2 is involved in the control of the cell cycle in neurons in the developing spinal cord of the zebrafish embryo. scratch2 knockdown induces postmitotic neurons to re-enter mitosis. Scratch2 prevents cell cycle re-entry by maintaining high levels of the cycle inhibitor p57 through the downregulation of miR-25. Thus, Scratch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-entry. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | The Society for Neuroscience | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.4459-12.2013 | - |
dc.relation.ispartof | Journal of Neuroscience, 2013, vol. 33, num. 12, p. 5095-5105 | - |
dc.relation.uri | https://doi.org/10.1523/JNEUROSCI.4459-12.2013 | - |
dc.rights | cc-by-nc-sa (c) Rodríguez-Aznar, Eva et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.classification | Mitosi | - |
dc.subject.classification | Neurones | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Factors de transcripció | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Metabolisme | - |
dc.subject.other | MicroRNAs | - |
dc.subject.other | Mitosis | - |
dc.subject.other | Neurons | - |
dc.subject.other | Physiology | - |
dc.subject.other | Transcription factors | - |
dc.subject.other | Genetics | - |
dc.subject.other | Metabolism | - |
dc.title | Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 624863 | - |
dc.date.updated | 2019-05-21T15:39:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23516276 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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624863.pdf | 3.27 MB | Adobe PDF | View/Open |
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