Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/133681
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pérez Salvia, Montserrat | - |
dc.contributor.author | Aldaba, Eneko | - |
dc.contributor.author | Vara, Yosu | - |
dc.contributor.author | Fabre, Myriam | - |
dc.contributor.author | Ferrer, Cristina | - |
dc.contributor.author | Masdeu, Carme | - |
dc.contributor.author | Zubia, Aizpea | - |
dc.contributor.author | San Sebastian, Eider | - |
dc.contributor.author | Otaegui, Dorleta | - |
dc.contributor.author | Llinàs-Arias, Pere | - |
dc.contributor.author | Rosselló-Tortella, Margalida | - |
dc.contributor.author | Berdasco, María | - |
dc.contributor.author | Moutinho, Cátia | - |
dc.contributor.author | Setién, Fernando | - |
dc.contributor.author | Villanueva Garatachea, Alberto | - |
dc.contributor.author | González Barca, Eva | - |
dc.contributor.author | Muncunill, Josep | - |
dc.contributor.author | Navarro, José-Tomás | - |
dc.contributor.author | Piris, Miguel A. | - |
dc.contributor.author | Cossio, Fernando P. | - |
dc.contributor.author | Esteller, Manel | - |
dc.date.accessioned | 2019-05-22T09:44:06Z | - |
dc.date.available | 2019-05-22T09:44:06Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/133681 | - |
dc.description.abstract | Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the tumoral epigenome is characterized by both specific and general shifts in the DNA methylation and histone-modification landscapes.1 However, in contrast to genetic disruption, the effect of epigenetic modifications or marks may potentially be reversed by the use of drugs that target enzymes involved in adding, removing or signaling DNA methylation and histone modifications.1 This basic knowledge has been adopted into clinical practice, and inhibitors of histone deacetylases and DNA demethylating agents have been approved for use in the therapy of hematologic malignancies, such as cutaneous T-cell lymphoma and myelodysplastic syndrome, respectively.2 Other promising epigenetic drugs include inhibitors of histone methyltransferases,2 histone demethylases,2 histone kinases,3 and bromodomain proteins that interfere with the 'reading' of acetylated histone residues. | - |
dc.format.extent | 1 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2018.189241 | - |
dc.relation.ispartof | Haematologica, 2018, vol. 103, num. 11, p. e537-e540 | - |
dc.relation.uri | https://doi.org/10.3324/haematol.2018.189241 | - |
dc.rights | (c) Ferrata Storti Foundation, 2018 | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Inhibidors enzimàtics | - |
dc.subject.classification | Histones | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Limfomes | - |
dc.subject.classification | Epigenètica | - |
dc.subject.other | Enzyme inhibitors | - |
dc.subject.other | Histones | - |
dc.subject.other | T cells | - |
dc.subject.other | Lymphomas | - |
dc.subject.other | Epigenetics | - |
dc.title | In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 687425 | - |
dc.date.updated | 2019-05-22T09:44:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29880608 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
687425.pdf | 991.75 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.