Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/133702
Title: An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures
Author: Collord, Grace
Tarpey, Patrick
Kurbatova, Natalja
Martincorena, Inigo
Moran, Sebastian
Castro de Moura, Manuel
Nagy, Tibor
Bignell, Graham
Maura, Francesco
Young, Matthew D.
Berna, Jorge
Tubio, Jose M. C.
McMurran, Chris E.
Young, Adam M. H.
Sanders, Mathijs
Noorani, Imran
Price, Stephen J.
Watts, Colin
Leipnitz, Elke
Kirsch, Matthias
Schackert, Gabriele
Pearson, Danita
Devadass, Abel
Ram, Zvi
Collins, V. Peter
Allinson, Kieren
Jenkinson, Michael D.
Zakaria, Rasheed
Syed, Khaja
Hanemann, C. Oliver
Dunn, Jemma
McDermott, Michael W.
Kirollos, Ramez W.
Vassiliou, George S.
Esteller, Manel
Behjati, Sam
Brazma, Alvis
Santarius, Thomas
McDermott, Ultan
Keywords: Meningioma
Tumors cerebrals
Genòmica
Metilació
Meningioma
Brain tumors
Genomics
Methylation
Issue Date: 10-Sep-2018
Publisher: Nature Publishing Group
Abstract: Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-31659-0
It is part of: Scientific Reports, 2018, vol. 8, num. 1, p. 13537
URI: http://hdl.handle.net/2445/133702
Related resource: https://doi.org/10.1038/s41598-018-31659-0
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Fisiològiques)

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