Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/133702
Title: | An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
Author: | Collord, Grace Tarpey, Patrick Kurbatova, Natalja Martincorena, Inigo Moran, Sebastian Castro de Moura, Manuel Nagy, Tibor Bignell, Graham Maura, Francesco Young, Matthew D. Berna, Jorge Tubio, Jose M. C. McMurran, Chris E. Young, Adam M. H. Sanders, Mathijs Noorani, Imran Price, Stephen J. Watts, Colin Leipnitz, Elke Kirsch, Matthias Schackert, Gabriele Pearson, Danita Devadass, Abel Ram, Zvi Collins, V. Peter Allinson, Kieren Jenkinson, Michael D. Zakaria, Rasheed Syed, Khaja Hanemann, C. Oliver Dunn, Jemma McDermott, Michael W. Kirollos, Ramez W. Vassiliou, George S. Esteller, Manel Behjati, Sam Brazma, Alvis Santarius, Thomas McDermott, Ultan |
Keywords: | Meningioma Tumors cerebrals Genòmica Metilació Meningioma Brain tumors Genomics Methylation |
Issue Date: | 10-Sep-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-31659-0 |
It is part of: | Scientific Reports, 2018, vol. 8, num. 1, p. 13537 |
URI: | http://hdl.handle.net/2445/133702 |
Related resource: | https://doi.org/10.1038/s41598-018-31659-0 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
687421.pdf | 2.7 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License