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http://hdl.handle.net/2445/133702
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DC Field | Value | Language |
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dc.contributor.author | Collord, Grace | - |
dc.contributor.author | Tarpey, Patrick | - |
dc.contributor.author | Kurbatova, Natalja | - |
dc.contributor.author | Martincorena, Inigo | - |
dc.contributor.author | Moran, Sebastian | - |
dc.contributor.author | Castro de Moura, Manuel | - |
dc.contributor.author | Nagy, Tibor | - |
dc.contributor.author | Bignell, Graham | - |
dc.contributor.author | Maura, Francesco | - |
dc.contributor.author | Young, Matthew D. | - |
dc.contributor.author | Berna, Jorge | - |
dc.contributor.author | Tubio, Jose M. C. | - |
dc.contributor.author | McMurran, Chris E. | - |
dc.contributor.author | Young, Adam M. H. | - |
dc.contributor.author | Sanders, Mathijs | - |
dc.contributor.author | Noorani, Imran | - |
dc.contributor.author | Price, Stephen J. | - |
dc.contributor.author | Watts, Colin | - |
dc.contributor.author | Leipnitz, Elke | - |
dc.contributor.author | Kirsch, Matthias | - |
dc.contributor.author | Schackert, Gabriele | - |
dc.contributor.author | Pearson, Danita | - |
dc.contributor.author | Devadass, Abel | - |
dc.contributor.author | Ram, Zvi | - |
dc.contributor.author | Collins, V. Peter | - |
dc.contributor.author | Allinson, Kieren | - |
dc.contributor.author | Jenkinson, Michael D. | - |
dc.contributor.author | Zakaria, Rasheed | - |
dc.contributor.author | Syed, Khaja | - |
dc.contributor.author | Hanemann, C. Oliver | - |
dc.contributor.author | Dunn, Jemma | - |
dc.contributor.author | McDermott, Michael W. | - |
dc.contributor.author | Kirollos, Ramez W. | - |
dc.contributor.author | Vassiliou, George S. | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Behjati, Sam | - |
dc.contributor.author | Brazma, Alvis | - |
dc.contributor.author | Santarius, Thomas | - |
dc.contributor.author | McDermott, Ultan | - |
dc.date.accessioned | 2019-05-22T11:56:12Z | - |
dc.date.available | 2019-05-22T11:56:12Z | - |
dc.date.issued | 2018-09-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/133702 | - |
dc.description.abstract | Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-31659-0 | - |
dc.relation.ispartof | Scientific Reports, 2018, vol. 8, num. 1, p. 13537 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-018-31659-0 | - |
dc.rights | cc-by (c) Collord, Grace et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Meningioma | - |
dc.subject.classification | Tumors cerebrals | - |
dc.subject.classification | Genòmica | - |
dc.subject.classification | Metilació | - |
dc.subject.other | Meningioma | - |
dc.subject.other | Brain tumors | - |
dc.subject.other | Genomics | - |
dc.subject.other | Methylation | - |
dc.title | An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 687421 | - |
dc.date.updated | 2019-05-22T11:56:13Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/716290/EU//SCUBA CANCERS | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30202034 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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687421.pdf | 2.7 MB | Adobe PDF | View/Open |
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