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Title: Cell Migration Driven by Cooperative Substrate Deformation Patterns
Author: Angelini, Thomas E.
Hannezo, Edouard
Trepat Guixer, Xavier
Fredberg, Jeffrey J.
Weitz, David A.
Keywords: Cèl·lules eucariotes
Migració cel·lular
Eukaryotic cells
Cell migration
Issue Date: 23-Apr-2010
Publisher: American Physical Society
Abstract: Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.
Note: Reproducció del document publicat a:
It is part of: Physical Review Letters, 2010, vol. 104, num. 16, p. 168104
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ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Biomedicina)

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