Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/134285
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dc.contributor.authorBadia Tahull, Maria Bella-
dc.contributor.authorLlop Talaverón, Josep Manuel-
dc.contributor.authorLeiva Badosa, Elisabet-
dc.contributor.authorBiondo, Sebastián-
dc.contributor.authorFarrán Teixidor, Leandre-
dc.contributor.authorRamon Torrell, Josep M. (Josep Maria)-
dc.contributor.authorJódar Masanés, Ramón José-
dc.date.accessioned2019-05-31T13:25:35Z-
dc.date.available2019-05-31T13:25:35Z-
dc.date.issued2010-09-
dc.identifier.issn0007-1145-
dc.identifier.urihttp://hdl.handle.net/2445/134285-
dc.description.abstractn-3 Fatty acids have clinical benefits. The primary aim of the present study was the assessment of infection in patients who underwent major high-risk elective gastrointestinal surgery receiving postoperatively fish oil (FO)-supplemented parenteral nutrition (PN), compared with those receiving a standard olive oil (OO) emulsion. The secondary aims were the assessment of anti-inflammatory response and evaluation of tolerance and safety of these emulsions. A prospective, randomised, double-blind study was performed in patients requiring at least 5 d of PN. An isoenergetic and isoproteic formula was administered: group A received OO alone, while group B received OO that was partially replaced with FO (16.6 %, w/w). End points were outcome measures (mortality, sepsis, infection, hospitalisation days and PN duration), inflammatory response (C-reactive protein (CRP), prealbumin and leucocytes) and safety (TAG and glucose metabolism, and liver and kidney function). Statistical analysis was done using Student's t test and Fisher's exact test (P < 0.05). Twenty-seven patients were evaluated, with thirteen patients receiving FO. In this group, a significantly lower incidence of infections was found (23.1 v. 78.6 %, P = 0.007). CRP, prealbumin and leucocytes were not significantly different between the groups. There were no differences in safety parameters. We conclude that high-risk surgical patients receiving FO-supplemented PN for 5 d present a lower incidence of infection. Emulsions were safe and well tolerated.-
dc.format.extent5 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherCambridge University Press-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1017/S0007114510001066-
dc.relation.ispartofBritish Journal of Nutrition, 2010, vol. 104, num. 5, p. 737-741-
dc.relation.urihttps://doi.org/10.1017/S0007114510001066-
dc.rights(c) Cambridge University Press, 2010-
dc.subject.classificationAgents antiinfecciosos-
dc.subject.classificationCirurgia-
dc.subject.classificationMalalties del tracte gastrointestinal-
dc.subject.classificationAlimentació parenteral-
dc.subject.classificationÚs terapèutic-
dc.subject.classificationEmulsions-
dc.subject.classificationOlis de peix-
dc.subject.classificationCura postoperatòria-
dc.subject.classificationProgrames de prevenció-
dc.subject.otherAnti-infective agents-
dc.subject.otherSurgery-
dc.subject.otherGastrointestinal system diseases-
dc.subject.otherParenteral feeding-
dc.subject.otherTherapeutic use-
dc.subject.otherEmulsions-
dc.subject.otherFish oils-
dc.subject.otherPostoperative care-
dc.subject.otherPrevention programs-
dc.titleA randomised study on the clinical progress of high-risk elective major gastrointestinal surgery patients treated with olive oil-based parenteral nutrition with or without a fish oil supplement-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec589931-
dc.date.updated2019-05-31T13:25:35Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid20350344-
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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