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http://hdl.handle.net/2445/134421
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DC Field | Value | Language |
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dc.contributor.author | Téllez i Besolí, Noèlia | - |
dc.contributor.author | Joanny Ordóñez, Géraldine | - |
dc.contributor.author | Escoriza, Jessica | - |
dc.contributor.author | Vilaseca Barceló, Marina | - |
dc.contributor.author | Montanya Mias, Eduard | - |
dc.date.accessioned | 2019-06-03T14:08:16Z | - |
dc.date.available | 2019-06-03T14:08:16Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/2445/134421 | - |
dc.description.abstract | β-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancreatic regeneration, rats underwent 95% Px or sham Px and were treated with [15 leu] gastrin-17 (Px+G and S+G) or vehicle (Px+V and S+V) for 15 d. In 95% Px rats, gastrin treatment reduced hyperglycemia (280 ± 52 mg vs. 436 ± 51 mg/dl, P < 0.05), and increased β-cell mass (1.15 ± 0.15 mg)) compared with vehicle-treated rats (0.67 ± 0.15 mg, P < 0.05). Gastrin treatment induced β-cell regeneration by enhancing β-cell neogenesis (increased number of extraislet β-cells in Px+G: 0.42 ± 0.05 cells/mm(2) vs. Px+V: 0.27 ± 0.07 cells/mm(2), P < 0.05, and pancreatic and duodenal homeobox 1 expression in ductal cells of Px+G: 1.21 ± 0.38% vs. Px+V: 0.23 ± 0.10%, P < 0.05) and replication (Px+G: 1.65 ± 0.26% vs. S+V: 0.64 ± 0.14%; P < 0.05). In addition, reduced β-cell apoptosis contributed to the increased β-cell mass in gastrin-treated rats (Px+G: 0.07 ± 0.02%, Px+V: 0.23 ± 0.05%; P < 0.05). Gastrin action on β-cell regeneration and survival increased β-cell mass and improved glucose tolerance in 95% Px rats, supporting a potential role of gastrin in the treatment of diabetes. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Association for the Study of Internal Secretions | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1210/en.2011-0066 | - |
dc.relation.ispartof | Endocrinology, 2011, vol. 152, num. 7, p. 2580-2588 | - |
dc.relation.uri | https://doi.org/10.1210/en.2011-0066 | - |
dc.rights | (c) Association for the Study of Internal Secretions, 2011 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Gastrina | - |
dc.subject.classification | Cèl·lules B | - |
dc.subject.classification | Glucosa | - |
dc.subject.classification | Tolerància | - |
dc.subject.classification | Ús terapèutic | - |
dc.subject.other | Gastrin | - |
dc.subject.other | B cells | - |
dc.subject.other | Glucose | - |
dc.subject.other | Toleration | - |
dc.subject.other | Therapeutic use | - |
dc.title | Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 602773 | - |
dc.date.updated | 2019-06-03T14:08:17Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21558313 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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602773.pdf | 789.3 kB | Adobe PDF | View/Open |
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