Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/134421
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTéllez i Besolí, Noèlia-
dc.contributor.authorJoanny Ordóñez, Géraldine-
dc.contributor.authorEscoriza, Jessica-
dc.contributor.authorVilaseca Barceló, Marina-
dc.contributor.authorMontanya Mias, Eduard-
dc.date.accessioned2019-06-03T14:08:16Z-
dc.date.available2019-06-03T14:08:16Z-
dc.date.issued2011-07-
dc.identifier.issn0013-7227-
dc.identifier.urihttp://hdl.handle.net/2445/134421-
dc.description.abstractβ-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancreatic regeneration, rats underwent 95% Px or sham Px and were treated with [15 leu] gastrin-17 (Px+G and S+G) or vehicle (Px+V and S+V) for 15 d. In 95% Px rats, gastrin treatment reduced hyperglycemia (280 ± 52 mg vs. 436 ± 51 mg/dl, P < 0.05), and increased β-cell mass (1.15 ± 0.15 mg)) compared with vehicle-treated rats (0.67 ± 0.15 mg, P < 0.05). Gastrin treatment induced β-cell regeneration by enhancing β-cell neogenesis (increased number of extraislet β-cells in Px+G: 0.42 ± 0.05 cells/mm(2) vs. Px+V: 0.27 ± 0.07 cells/mm(2), P < 0.05, and pancreatic and duodenal homeobox 1 expression in ductal cells of Px+G: 1.21 ± 0.38% vs. Px+V: 0.23 ± 0.10%, P < 0.05) and replication (Px+G: 1.65 ± 0.26% vs. S+V: 0.64 ± 0.14%; P < 0.05). In addition, reduced β-cell apoptosis contributed to the increased β-cell mass in gastrin-treated rats (Px+G: 0.07 ± 0.02%, Px+V: 0.23 ± 0.05%; P < 0.05). Gastrin action on β-cell regeneration and survival increased β-cell mass and improved glucose tolerance in 95% Px rats, supporting a potential role of gastrin in the treatment of diabetes.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAssociation for the Study of Internal Secretions-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1210/en.2011-0066-
dc.relation.ispartofEndocrinology, 2011, vol. 152, num. 7, p. 2580-2588-
dc.relation.urihttps://doi.org/10.1210/en.2011-0066-
dc.rights(c) Association for the Study of Internal Secretions, 2011-
dc.subject.classificationGastrina-
dc.subject.classificationCèl·lules B-
dc.subject.classificationGlucosa-
dc.subject.classificationTolerància-
dc.subject.classificationÚs terapèutic-
dc.subject.otherGastrin-
dc.subject.otherB cells-
dc.subject.otherGlucose-
dc.subject.otherToleration-
dc.subject.otherTherapeutic use-
dc.titleGastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec602773-
dc.date.updated2019-06-03T14:08:17Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid21558313-
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
602773.pdf789.3 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.