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dc.contributor.authorPalassini, Matteo-
dc.contributor.authorRitort Farran, Fèlix-
dc.description.abstractWe derive analytical expressions for the bias of the Jarzynski free-energy estimator from N nonequilibrium work measurements, for a generic work distribution. To achieve this, we map the estimator onto the random energy model in a suitable scaling limit parametrized by ( log  N ) / μ , where μ measures the width of the lower tail of the work distribution, and then compute the finite- N corrections to this limit with different approaches for different regimes of ( log  N ) / μ . We show that these expressions describe accurately the bias for a wide class of work distributions and exploit them to build an improved free-energy estimator from unidirectional work measurements. We apply the method to optical tweezers unfolding and refolding experiments on DNA hairpins of varying loop size and dissipation, displaying both near-Gaussian and non-Gaussian work distributions.-
dc.format.extent5 p.-
dc.publisherAmerican Physical Society-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofPhysical Review Letters, 2011, vol. 107, num. 6, p. 060601-
dc.rights(c) American Physical Society, 2011-
dc.subject.classificationFísica de partícules-
dc.subject.otherParticle physics-
dc.titleImproving Free-Energy Estimates from Unidirectional Work Measurements: Theory and Experiment-
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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