Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/134938
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Barbosa Torralbo, José | - |
dc.contributor.author | Sanz Nebot, María Victoria | - |
dc.contributor.author | Benavente Moreno, Fernando J. (Julián) | - |
dc.contributor.author | Giménez López, Estela | - |
dc.date.accessioned | 2019-06-12T10:11:28Z | - |
dc.date.available | 2019-06-12T10:11:28Z | - |
dc.date.issued | 2006-06-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/134938 | - |
dc.description.abstract | Glycosylation is the most common posttranslational modification in proteins and the carbohydrates participate in many biological processes. The number and type of glycoforms for a certain glycoprotein may change as a consequence of pathological processes. In our work a method for the separation of transferrin sialoforms has been developed, that permits the diagnostic of Congenital Disorders of Glycosylation (CDG) using a polybrene-dextran sulphate coating and CE-ESI-TOF methodologies. In order to improve the sensitivity the use of solid-phase extraction coupled on-line to CE-ESI-MS is studied and the SPE-CE-ESI-MS developed methods are applied for the characterization of rHuEPO glycoforms. The achieved separation and the high mass-resolving power of flight (TOF) mass detection allows to establish the most probable rHuEPO glycoforms. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | http://dergi.fabad.org.tr/pdf/volum31/issue2/63-69.pdf | - |
dc.relation.ispartof | FABAD Journal of Pharmaceutical Sciences, 2006, vol. 31, p. 63-69 | - |
dc.rights | , 2006 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Electroforesi capil·lar | - |
dc.subject.classification | Glicoproteïnes | - |
dc.subject.classification | Espectrometria de masses | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Capillary electrophoresis | - |
dc.subject.other | Glycoproteins | - |
dc.subject.other | Mass spectrometry | - |
dc.subject.other | Proteins | - |
dc.title | Characterization of glycoproteins by capillary electrophoresis electrospray mass spectrometry (CE-ESI-MS). Applications to diagnosis in biomedicine | - |
dc.type | info:eu-repo/semantics/article | - |
dc.identifier.idgrec | 551918 | - |
dc.date.updated | 2019-06-12T10:11:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
551918.pdf | 1.82 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.