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DC Field | Value | Language |
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dc.contributor.author | Tom, Robby Zachariah | - |
dc.contributor.author | García-Roves, Pablo M. (Pablo Miguel) | - |
dc.contributor.author | Sjögren, Rasmus J. O. | - |
dc.contributor.author | Jiang, Lake Q. | - |
dc.contributor.author | Holmström, Maria H. | - |
dc.contributor.author | Deshmukh, Atul S. | - |
dc.contributor.author | Vieira, Elaine | - |
dc.contributor.author | Chibalin, Alexander V. | - |
dc.contributor.author | Björnholm, Marie | - |
dc.contributor.author | Zierath, Juleen R. | - |
dc.date.accessioned | 2019-06-13T15:48:40Z | - |
dc.date.available | 2019-06-13T15:48:40Z | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/2445/135010 | - |
dc.description.abstract | AMP-activated protein kinase (AMPK) is a heterotrimeric complex, composed of a catalytic subunit (α) and two regulatory subunits (β and γ), which act as a metabolic sensor to regulate glucose and lipid metabolism. A mutation in the γ3 subunit (AMPKγ3(R225Q)) increases basal AMPK phosphorylation, while concomitantly reducing sensitivity to AMP. AMPKγ3(R225Q) (γ3(R225Q)) transgenic mice are protected against dietary-induced triglyceride accumulation and insulin resistance. We determined whether skeletal muscle-specific expression of AMPKγ3(R225Q) prevents metabolic abnormalities in leptin-deficient ob/ob (ob/ob-γ3(R225Q)) mice. Glycogen content was increased, triglyceride content was decreased, and diacylglycerol and ceramide content were unaltered in gastrocnemius muscle from ob/ob-γ3(R225Q) mice, whereas glucose tolerance was unaltered. Insulin-stimulated glucose uptake in extensor digitorum longus muscle during the euglycemic-hyperinsulinemic clamp was increased in lean γ3(R225Q) mice, but not in ob/ob-γ3(R225Q) mice. Acetyl-CoA carboxylase phosphorylation was increased in gastrocnemius muscle from γ3(R225Q) mutant mice independent of adiposity. Glycogen and triglyceride content were decreased after leptin treatment (5 days) in ob/ob mice, but not in ob/ob-γ3(R225Q) mice. In conclusion, metabolic improvements arising from muscle-specific expression of AMPKγ3(R225Q) are insufficient to ameliorate insulin resistance and obesity in leptin-deficient mice. Central defects due to leptin deficiency may override any metabolic benefit conferred by peripheral overexpression of the AMPKγ3(R225Q) mutation. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Diabetes Association | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2337/db13-0670 | - |
dc.relation.ispartof | Diabetes, 2014, vol. 63, num. 5, p. 1560-1571 | - |
dc.relation.uri | https://doi.org/10.2337/db13-0670 | - |
dc.rights | cc-by-nc-nd (c) American Diabetes Association, 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Resistència a la insulina | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Leptina | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Músculs | - |
dc.subject.classification | Esquelet | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Insulin resistance | - |
dc.subject.other | Physiology | - |
dc.subject.other | Leptin | - |
dc.subject.other | Genetics | - |
dc.subject.other | Muscles | - |
dc.subject.other | Skeleton | - |
dc.subject.other | Obesity | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.title | Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 650516 | - |
dc.date.updated | 2019-06-13T15:48:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24487023 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
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