Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/135119
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dc.contributor.authorBeguiristain, Iñaki-
dc.contributor.authorAlongi, Angelina-
dc.contributor.authorRúbies Prat, Antoni-
dc.contributor.authorGranados i Juan, Mercè-
dc.date.accessioned2019-06-14T11:36:11Z-
dc.date.issued2018-11-26-
dc.identifier.issn1618-2642-
dc.identifier.urihttp://hdl.handle.net/2445/135119-
dc.description.abstractA rapid and sensitive method for the confirmatory analysis of 8 synthetic corticosteroids (betamethasone, dexamethasone, prednisolone, 6 methyl prednisolone, triamcinolone, flumethasone, beclomethasone, fluocinolone acetonide) is proposed. The method is useful for detecting illegal treatments in different animal species. It consists of an extraction and clean-up using the Quick Easy Cheap Effective Rugged Safe (QuEChERS) strategy. Quantitative determination is achieved by ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry with heated electrospray ionization in negative mode. Quantification is performed using surrogate matrix matched standard calibration curve with dexamethasone-D4 as the internal standard. The method was validated for analyzing liver samples according to the criteria established by Decision 2002/657/EC. Linearity was assessed in the 1-10 μg kg-1 range and linear correlation coefficients were over 0.99 for all the analytes. CCα ranged from 0.04 to 0.16 μg kg-1 for substances without maximum residue limit. The method allows confident quantification and confirmation of corticosteroids in liver samples, and its simplicity makes it suitable for analyzing large numbers of samples.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer Verlag-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1007/s00216-018-1459-y-
dc.relation.ispartofAnalytical and Bioanalytical Chemistry, 2018, vol. 411, num. 2, p. 449-457-
dc.relation.urihttps://doi.org/10.1007/s00216-018-1459-y-
dc.rights(c) Springer Verlag, 2018-
dc.subject.classificationCromatografia de líquids-
dc.subject.classificationEspectrometria de masses-
dc.subject.otherLiquid chromatography-
dc.subject.otherMass spectrometry-
dc.titleAnalysis of corticosteroids in samples of animal origin using QuEChERS and ultrahigh-performance liquid chromatography coupled to high-resolution mass spectrometry.-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec686311-
dc.date.updated2019-06-14T11:36:11Z-
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess-
dc.embargo.lift2019-11-26-
dc.date.embargoEndDateinfo:eu-repo/date/embargoEnd/2019-11-26-
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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