Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/135124
Title: A role for the host in the roadmap to diabetes stem cell therapy
Author: Soria, Bernat
Montanya Mias, Eduard
Martín, Franz
Hmadcha, Abdelkrim
Keywords: Diabetis
Cèl·lules mare
Teràpia cel·lular
Diabetes
Stem cells
Cellular therapy
Issue Date: May-2016
Publisher: American Diabetes Association
Abstract: Stem cells represent an unlimited source for cell therapy (1), and considerable efforts have been made to overcome barriers to introducing this revolutionary therapy into clinical practice. Briefly, the following actions must be taken: 1) design in vitro differentiation strategies to generate either mature postmitotic b-cells or b-cell progenitors that may be safely implanted into the host (e.g., without uncontrolled proliferation), 2) devise selection methods to produce a pure b-cell population, 3) validate standard characterization protocols to determine the real differentiation stage of the cells ready to be transplanted, 4) obtain encapsulation devices to implant the cells, 5) develop preclinical controls in representative animal models, and 6) de fine cell-host interactions (for a recent review see ref. 2)
Note: Reproducció del document publicat a: https://doi.org/10.2337/dbi16-0003
It is part of: Diabetes, 2016, vol. 65, num. 5, p. 1155-1157
URI: http://hdl.handle.net/2445/135124
Related resource: https://doi.org/10.2337/dbi16-0003
ISSN: 0012-1797
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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