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http://hdl.handle.net/2445/135189
Title: | Evolution of the gut microbiome following acute HIV-1 infection |
Author: | Rocafort, Muntsa Noguera Julian, Marc Rivera, Javier Pastor, Lucía Guillén, Yolanda Langhorst, Jost Parera, Mariona Mandomando, Inácio Carrillo, Jorge Urrea, Victor Rodríguez, Cristina Casadellà, Maria Calle, María Luz Clotet, Bonaventura, 1953- Blanco, Julià Naniche, Denise Paredes, Roger |
Keywords: | Microbiota Infeccions per VIH HIV infections |
Issue Date: | 11-May-2019 |
Publisher: | BioMed Central |
Abstract: | Background: In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed with recent HIV-1 infection (RHI) and 54 HIV-1-negative controls for 9–18 months and compared them with 98 chronically HIV-1- infected subjects treated with antiretrovirals (n = 27) or not (n = 71). Results: We show that RHI is followed by increased fecal adenovirus shedding, which persists during chronic HIV-1 infection and does not resolve with ART. Recent HIV-1 infection is also followed by transient non-HIV-specific changes in the gut bacterial richness and composition. Despite early resilience to change, an HIV-1-specific signature in the gut bacteriome—featuring depletion of Akkermansia, Anaerovibrio, Bifidobacterium, and Clostridium—previously associated with chronic inflammation, CD8+ T cell anergy, and metabolic disorders, can be eventually identified in chronically HIV-1-infected subjects. Conclusions: Recent HIV-1 infection is associated with increased fecal shedding of eukaryotic viruses, transient loss of bacterial taxonomic richness, and long-term reductions in microbial gene richness. An HIV-1-associated microbiome signature only becomes evident in chronically HIV-1-infected subjects. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1186/s40168-019-0687-5 |
It is part of: | Microbiome, 2019, vol. 7, num. 73 |
URI: | http://hdl.handle.net/2445/135189 |
Related resource: | http://dx.doi.org/10.1186/s40168-019-0687-5 |
ISSN: | 2049-2618 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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RocafortM_Microbiome_2019.pdf | 6.17 MB | Adobe PDF | View/Open |
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