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http://hdl.handle.net/2445/135361
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DC Field | Value | Language |
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dc.contributor.author | Marques, Joana | - |
dc.contributor.author | Valle Delgado, Juan José | - |
dc.contributor.author | Urbán, Patricia | - |
dc.contributor.author | Baró, Elisabet | - |
dc.contributor.author | Prohens López, Rafael | - |
dc.contributor.author | Mayor Aparicio, Alfredo Gabriel | - |
dc.contributor.author | Cisteró, Pau | - |
dc.contributor.author | Delves, Michael | - |
dc.contributor.author | Sinden, Robert E. | - |
dc.contributor.author | Grandfils, Christian | - |
dc.contributor.author | Paz, José L. de | - |
dc.contributor.author | García Salcedo, José A. | - |
dc.contributor.author | Fernàndez Busquets, Xavier | - |
dc.date.accessioned | 2019-06-18T15:24:07Z | - |
dc.date.available | 2019-06-18T15:24:07Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1549-9634 | - |
dc.identifier.uri | http://hdl.handle.net/2445/135361 | - |
dc.description.abstract | The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1016/j.nano.2016.09.010 | - |
dc.relation.ispartof | Nanomedicine: Nanotechnology, Biology and Medicine, 2017, vol. 13, num. 2, p. 515-525 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.nano.2016.09.010 | - |
dc.rights | cc by (c) Marques et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Nanomedicina | - |
dc.subject.other | Malaria | - |
dc.subject.other | Nanomedicine | - |
dc.title | Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2019-06-14T09:57:17Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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MarquesJ_Nanomedicine_2017.pdf | 1.42 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License