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Title: Does Progressive Introduction of Benznidazole Reduce the Chance of Adverse Events in the Treatment of Chagas Disease?
Author: Losada, Irene
Madrid Pascual, Olaya
Herrero Martínez, Juan María
Pérez Ayala, Ana
Lizasoain Hernández, Manuel
Keywords: Malaltia de Chagas
Chagas' disease
Issue Date: 5-Jun-2019
Publisher: The American Society of Tropical Medicine and Hygiene
Abstract: In this retrospective cohort study, we aimed to assess whether introducing benznidazole at escalating doses reduces the probability of adverse events or treatment discontinuation compared with a full-dose scheme. We collected data from patients who had chronic " - " infection and underwent treatment from July 2008 to January 2017 in a referral center in Madrid. Dose was adjusted to body weight (5 mg/kg/day), with treatment introduction with full dose or escalating dose according to local consensus and protocols. Among the 62 patients treated, benznidazole was introduced at full dose in 28 patients and on escalating dose in the remaining 34. We found no statistical differences in the number of adverse events, treatment discontinuations, days of treatment, or sociodemographic profiles. There is insufficient evidence to support escalating dose as a strategy for reducing the adverse effects of benznidazole. Further research is needed to evaluate this strategy.
Note: Versió postprint del document publicat a:
It is part of: American Journal of Tropical Medicine and Hygiene, 2019, vol. 100, num. 6, p. 1477-1481
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ISSN: 0002-9637
Appears in Collections:Articles publicats en revistes (ISGlobal)

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