Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/135643
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cathomas, Richard | - |
dc.contributor.author | Klingbiel, Dirk | - |
dc.contributor.author | Bernard, Brandon | - |
dc.contributor.author | Lorch, Anja | - |
dc.contributor.author | García del Muro Solans, Xavier | - |
dc.contributor.author | Morelli, Franco | - |
dc.contributor.author | Giorgi, Ugo de | - |
dc.contributor.author | Fedyanin, Mikhail | - |
dc.contributor.author | Oing, Christoph | - |
dc.contributor.author | Haugnes, Hege Sagstuen | - |
dc.contributor.author | Hentrich, Marcus | - |
dc.contributor.author | Fankhauser, Christian | - |
dc.contributor.author | Gillessen, Silke | - |
dc.contributor.author | Beyer, Jörg | - |
dc.date.accessioned | 2019-06-20T10:54:20Z | - |
dc.date.available | 2019-06-20T10:54:20Z | - |
dc.date.issued | 2018-10-04 | - |
dc.identifier.issn | 0732-183X | - |
dc.identifier.uri | http://hdl.handle.net/2445/135643 | - |
dc.description.abstract | Purpose Residual lesions after chemotherapy are frequent in metastatic seminoma. Watchful waiting is recommended for lesions < 3 cm as well as for fluorodeoxyglucose (FDG) positron emission tomography (PET)-negative lesions ≥ 3 cm. Information on the optimal management of PET-positive residual lesions ≥ 3 cm is lacking. Patients and Methods We retrospectively identified 90 patients with metastatic seminoma with PET-positive residual lesions after chemotherapy. Patients with elevated α-fetoprotein or nonseminomatous histology were excluded. We analyzed the post-PET management and its impact on relapse and survival and calculated the positive predictive value (PPV) for PET. Results Median follow-up time was 29 months (interquartile range [IQR], 10 to 62 months). Median diameter of the largest residual mass was 4.9 cm (range, 1.1 to 14 cm), with masses located in the retroperitoneum (77%), pelvis (16%), mediastinum (17%), and/or lung (3%). Median time from the last day of chemotherapy to PET was 6.9 weeks (IQR, 4.4 to 9.9 weeks). Post-PET management included repeated imaging in 51 patients (57%), resection in 26 patients (29%), biopsy in nine patients (10%) and radiotherapy in four patients (4%). Histology of the resected specimen was necrosis in 21 patients (81%) and vital seminoma in five patients (19%). No biopsy revealed vital seminoma. Relapse or progression occurred in 15 patients (17%) after a median of 3.7 months (IQR, 2.5 to 4.9 months) and was found in 11 (22%) of 51 patients on repeated imaging, in two (8%) of 26 patients after resection, and in two (22%) of nine patients after biopsy. All but one patient who experienced relapse were successfully treated with salvage therapy. The PPV for FDG-PET was 23%. Conclusion FDG-PET has a low PPV for vital tumor in residual lesions after chemotherapy in patients with metastatic seminoma. This cautions against clinical decisions based on PET positivity alone. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society of Clinical Oncology | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1200/JCO.18.00210 | - |
dc.relation.ispartof | Journal of Clinical Oncology, 2018, vol. 36, num. 34, p. 3381-3387 | - |
dc.relation.uri | https://doi.org/10.1200/JCO.18.00210 | - |
dc.rights | (c) American Society of Clinical Oncology, 2018 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Quimioteràpia | - |
dc.subject.classification | Tomografia per emissió de positrons | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Chemotherapy | - |
dc.subject.other | Positron emission tomography | - |
dc.subject.other | Cancer | - |
dc.title | Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 688180 | - |
dc.date.updated | 2019-06-20T10:54:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
688180.pdf | 584.02 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.