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http://hdl.handle.net/2445/137201
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DC Field | Value | Language |
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dc.contributor.author | Dierssen Sotos, Trinidad | - |
dc.contributor.author | Palazuelos-Calderón, Camilo | - |
dc.contributor.author | Jiménez Moleón, José Juan | - |
dc.contributor.author | Aragonès Sanz, Núria | - |
dc.contributor.author | Altzibar, Jone M. | - |
dc.contributor.author | Castaño-Vinyals, Gemma | - |
dc.contributor.author | Martín Sánchez, Vicente | - |
dc.contributor.author | Gómez Acebo, Inés | - |
dc.contributor.author | Guevara, Marcela | - |
dc.contributor.author | Tardón, Adonina | - |
dc.contributor.author | Pérez Gómez, Beatriz | - |
dc.contributor.author | Amiano, Pilar | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Molina de la Torre, Antonio José | - |
dc.contributor.author | Alonso Molero, Jéssica | - |
dc.contributor.author | Moreno Iribas, Conchi | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Pollán, Marina | - |
dc.contributor.author | Llorca Díaz, Javier | - |
dc.date.accessioned | 2019-07-15T11:02:28Z | - |
dc.date.available | 2019-07-15T11:02:28Z | - |
dc.date.issued | 2018-03-12 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | http://hdl.handle.net/2445/137201 | - |
dc.description.abstract | BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12885-018-4182-3 | - |
dc.relation.ispartof | BMC Cancer, 2018, vol. 18, p. 280 | - |
dc.relation.uri | https://doi.org/10.1186/s12885-018-4182-3 | - |
dc.rights | cc-by (c) Dierssen Sotos, Trinidad et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Reproducció humana | - |
dc.subject.classification | Genètica | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Human reproduction | - |
dc.subject.other | Genetics | - |
dc.title | Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 685308 | - |
dc.date.updated | 2019-07-15T11:02:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29530003 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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685308.pdf | 586.53 kB | Adobe PDF | View/Open |
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