Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/137238
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Narváez García, Francisco Javier | - |
dc.contributor.author | Borrell, Helena | - |
dc.contributor.author | Sánchez Alonso, Fernando | - |
dc.contributor.author | Rúa Figueroa, Iñigo | - |
dc.contributor.author | López Longo, Francisco J. | - |
dc.contributor.author | Galindo Izquierdo, María | - |
dc.contributor.author | Calvo Alén, Jaime | - |
dc.contributor.author | Fernández Nebro, Antonio | - |
dc.contributor.author | Olivé Marqués, Alejandro | - |
dc.contributor.author | Andreu, José Luis | - |
dc.contributor.author | Martínez Taboada, Víctor Manuel | - |
dc.contributor.author | Nolla Solé, Joan Miquel | - |
dc.contributor.author | Pego Reigosa, José María | - |
dc.contributor.author | RELESSER Study Group | - |
dc.date.accessioned | 2019-07-15T10:18:32Z | - |
dc.date.available | 2019-07-15T10:18:32Z | - |
dc.date.issued | 2018-12-19 | - |
dc.identifier.issn | 1478-6362 | - |
dc.identifier.uri | http://hdl.handle.net/2445/137238 | - |
dc.description.abstract | Background The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort. Methods All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology [SER], cross-sectional phase) registry were retrospectively investigated for the presence of primary pleuropulmonary manifestations. Results In total 3215 patients were included. At least one pleuropulmonary manifestation was present in 31% of patients. The most common manifestation was pleural disease (21%), followed by lupus pneumonitis (3.6%), pulmonary thromboembolism (2.9%), primary pulmonary hypertension (2.4%), diffuse interstitial lung disease (2%), alveolar hemorrhage (0.8%), and shrinking lung syndrome (0.8%). In the multivariable analysis, the variables associated with the development of pleuropulmonary manifestation were older age at disease onset (odds ratio (OR) 1.03, 95% confidence interval (CI) 1.02-1.04), higher SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) scores (OR 1.03, 95% CI 1.00-1.07), the presence of Raynaud's phenomenon (OR 1.41, 95% CI 1.09-1.84), secondary antiphospholipid syndrome (OR 2.20, 95% CI 1.63-2.97), and the previous or concomitant occurrence of severe lupus nephritis, (OR 1.48, 95% CI 1.12-1.95) neuropsychiatric manifestations (OR 1.49, 95% CI 1.11-2.02), non-ischemic cardiac disease (OR 2.91, 95% CI 1.90-4.15), vasculitis (OR 1.81, 95% CI 1.25-2.62), hematological manifestations (OR 1.31, 95% CI 1.00-1.71), and gastrointestinal manifestations, excluding hepatitis (OR 2.05, 95% CI 1.14-3.66). Anti-RNP positivity had a clear tendency to significance (OR 1.32, 95% CI 1.00-1.75; P = 0.054). The development of pleuropulmonary manifestations independently contributes to a diminished survival (hazard ratio of 3.13). However, not all complications will influence the prognosis in the same way. Whereas the occurrence of pleural disease or pulmonary thromboembolism has a minimal impact on the survival of these patients, the remaining manifestations have a major impact on mortality. Conclusion Except for pleural disease, the remaining respiratory manifestations are very uncommon in SLE (<4%). Pleuropulmonary manifestations independently contributed to a decreased survival in these patients. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s13075-018-1776-8 | - |
dc.relation.ispartof | Arthritis Research & Therapy, 2018, vol. 20, num. 1, p. 280 | - |
dc.relation.uri | https://doi.org/10.1186/s13075-018-1776-8 | - |
dc.rights | cc-by (c) Narváez García, Francisco Javier et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Lupus eritematós | - |
dc.subject.classification | Malalties de la pleura | - |
dc.subject.classification | Malalties del pulmó | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Lupus erythematosus | - |
dc.subject.other | Pleural disease | - |
dc.subject.other | Pulmonary diseases | - |
dc.subject.other | Prognosis | - |
dc.title | Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 684299 | - |
dc.date.updated | 2019-07-15T10:18:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30567600 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
684299.pdf | 631.41 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License