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Title: Kidins220 correlates with tau in Alzheimer's disease brain and cerebrospinal fluid
Author: Gamir Morralla, Andrea
Belbin, Olivia
Fortea Ormaechea, Juan
Alcolea, Daniel
Ferrer, Isidro (Ferrer Abizanda)
Lleó Bisa, Alberto
Iglesias, Teresa
Keywords: Malaltia d'Alzheimer
Líquid cefalorraquidi
Proteïnes de membrana
Alzheimer's disease
Cerebrospinal fluid
Membrane proteins
Issue Date: Aug-2017
Publisher: IOS Press
Abstract: Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer's disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, in the brain and cerebrospinal fluid (CSF) of controls and AD patients. Only the N-terminal antibody showed a positive correlation between Kidins220 and phosphorylated tau in AD brains. Using this antibody, Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. This study highlights the potential of Kidins220 as a CSF biomarker in AD.
Note: Versió postprint del document publicat a:
It is part of: Journal of Alzheimer's Disease, 2017, vol. 55, num. 4, p. 1327-1333
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ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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