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Title: Molecular links between early energy metabolism alterations and Alzheimer´s disease
Author: Pedros, Ignacio
Patraca, Ivan
Martinez, Nohora
Petrov, Dmitry
Sureda, Francesc X.
Auladell i Costa, M. Carme
Beas Zárate, Carlos
Folch, Jaume
Keywords: Malaltia d'Alzheimer
Metabolisme energètic
Alzheimer's disease
Energy metabolism
Issue Date: 1-Jan-2016
Publisher: Frontiers in Bioscience
Abstract: Recent studies suggest that the neurobiology of Alzheimer's disease (AD) pathology could not be explained solely by an increase in beta-amyloid levels. In fact, success with potential therapeutic drugs that inhibit the generation of beta amyloid has been low. Therefore, due to therapeutic failure in recent years, the scientists are looking for alternative hypotheses to explain the causes of the disease and the cognitive loss. Accordingly, alternative hypothesis propose a link between AD and peripheral metabolic alteration. Then, we review in depth changes related to insulin signalling and energy metabolism in the context of the APPSwe/PS1dE9 (APP/PS1) mice model of AD. We show an integrated view of the changes that occur in the early stages of the amyloidogenic process in the APP/PS1 double transgenic mice model. These early changes affect several key metabolic processes related to glucose uptake and insulin signalling, cellular energy homeostasis, mitochondrial biogenesis and increased Tau phosphorylation by kinase molecules like mTOR and Cdk5.
Note: Versió postprint del document publicat a:
It is part of: Frontiers in Bioscience-Landmark Edition, 2016, vol. 1, num. 21, p. 8-19
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ISSN: 1093-9946
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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