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Title: Epigenetics in the eye: an overview of the most relevant ocular diseases
Author: Alkozi, Hanan A.
Franco Fernández, Rafael
Pintor, Jesús J.
Keywords: Epigenètica
Manifestacions oculars de les malalties
Ocular manifestations of general diseases
Issue Date: 12-Oct-2017
Publisher: Frontiers Media
Abstract: Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.
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It is part of: Frontiers In Genetics, 2017, vol. 8, p. 144
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ISSN: 1664-8021
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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