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dc.contributor.authorAlmendros López, Isaac-
dc.contributor.authorCarreras, Alba-
dc.contributor.authorMontserrat Canal, José Ma.-
dc.contributor.authorGozal, David-
dc.contributor.authorNavajas Navarro, Daniel-
dc.contributor.authorFarré Ventura, Ramon-
dc.description.abstractAdult stem cells are undifferentiated cells that can be mobilized from the bone marrow or other organs, home into injured tissues, and differentiate into different cell phenotypes to serve in a repairing capacity. Furthermore, these cells can respond to inflammation and oxidative stress by exhibiting immunomodulatory properties. The protective and reparative roles of mesenchymal stem cells (MSCs), very small embryonic-like stem cells (VSELs), and endothelial progenitor cells (EPCs) have primarily been examined and characterized in auto-immune and cardiovascular diseases. Obstructive sleep apnea (OSA) is a very prevalent disease (4-5% of adult population and 2-3% of children) characterized by an abnormal increase in upper airway collapsibility. Recurrent airway obstructions elicit arterial oxygen desaturations, increased inspiratory efforts, and sleep fragmentation, which have been associated with important long-term neurocognitive, metabolic, and cardiovascular consequences. Since inflammation, oxidative stress and endothelial dysfunction are key factors in the development of the morbid consequences of OSA, bone marrow-derived stem cells could be important modulators of the morbid phenotype by affording a protective role. This mini-review is focused on the recent data available on EPCs, VSELs, and MSCs in both animal models and patients with OSA.-
dc.format.extent6 p.-
dc.publisherFrontiers Media-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofFrontiers In Neurology, 2012, vol. 3-
dc.rightscc-by (c) Almendros López, Isaac et al., 2012-
dc.subject.classificationSíndromes d'apnea del son-
dc.subject.classificationCèl·lules mare-
dc.subject.otherSleep apnea syndromes-
dc.subject.otherStem cells-
dc.titlePotential role of adult stem cells in obstructive sleep apnea-
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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