Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/140448
Title: Aging dependent effect of nuclear tau
Author: Gil, Laura
Federico, Concetta
Pinedo, Fernando
Bruno, Francesca
Rebolledo, Ana B.
Montoya, Juan J.
Olazabal, Isabel M.
Ferrer, Isidro (Ferrer Abizanda)
Saccone, Salvatore
Keywords: Envelliment
Metabolisme
Nuclis cel·lulars
Fisiologia
Hipocamp (Cervell)
Aging
Metabolism
Cell nuclei
Physiology
Hippocampus (Brain)
Issue Date: Dec-2017
Publisher: Elsevier B.V.
Abstract: Tau protein is characterized by a complex pattern of phosphorylation and is localized in the cytoplasm and nucleus in both neuronal and non-neuronal cells. Human AT100 nuclear tau, endowed by phosphorylation in Thr212/Ser214, was recently shown to decline in cornus ammonis 1 (CA1) and dentate gyrus (DG) in Alzheimer's disease (AD), but a defined function for this nuclear tau remains unclear. Here we show that AT100 progressively increases in the nuclei of neuronal and non-neuronal cells during aging, and decreases in the more severe AD stages, as recently shown, and in cancer cells (colorectal adenocarcinoma and breast cancer). AT100, in addition to a co-localization with the DAPIpositive heterochromatin, was detected in the nucleolus of pyramidal cells from the CA1 region, shown to be at its highest level in the more senescent cells and in the first stage of AD (ADI), and disappearing in the more severe AD cases (ADIV). Taking into account the nuclear distribution of AT100 during cell aging and its relation to the chromatin changes observed in degenerated neurons, as well as in cancerous cells, which are both cellular pathologies associated with age, we can consider the Thr212/Ser214 phosphorylated nuclear tau as a molecular marker of cell aging.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.brainres.2017.09.030
It is part of: Brain Research Bulletin, 2017, vol. 1677, p. 129-137
URI: http://hdl.handle.net/2445/140448
Related resource: https://doi.org/10.1016/j.brainres.2017.09.030
ISSN: 0361-9230
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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