Please use this identifier to cite or link to this item:
Title: Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
Author: Terré, Berta
Lewis, Michael T.
Gil Gómez, Gabriel
Han, Zhiyuan
Lu, Hao
Aguilera, Mònica
Prats, Neus
Roy, Sudipto
Zhao, Haotian
Stracker, Travis H.
Keywords: Esterilitat
Issue Date: 23-Apr-2019
Publisher: The Company of Biologists
Abstract: GEMC1 and MCIDAS are geminin family proteins that transcriptionally activate E2F4/5-target genes during multiciliogenesis, including Foxj1 and Ccno. Male mice that lacked Gemc1, Mcidas or Ccno were found to be infertile, but the origin of this defect has remained unclear. Here, we show that all three genes are necessary for the generation of functional multiciliated cells in the efferent ducts that are required for spermatozoa to enter the epididymis. In mice that are mutant for Gemc1, Mcidas or Ccno, we observed a similar spectrum of phenotypes, including thinning of the seminiferous tubule epithelia, dilation of the rete testes, sperm agglutinations in the efferent ducts and lack of spermatozoa in the epididymis (azoospermia). These data suggest that defective efferent duct development is the dominant cause of male infertility in these mouse models, and this likely extends to individuals with the ciliopathy reduced generation of multiple motile cilia with mutations in MCIDAS and CCNO.
Note: Versió postprint del document publicat a:
It is part of: Development, 2019, vol. 146, num. 8
Related resource:
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Files in This Item:
File Description SizeFormat 
terre-manuscript.pdf294.02 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.