Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/140957
Title: Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target
Author: Jove, Mariona
Pradas, Irene
Domínguez González, Mayelín
Ferrer, Isidro (Ferrer Abizanda)
Pamplona, Reinald
Keywords: Envelliment
Antioxidants
Citosquelet
Metabolisme energètic
Estrès oxidatiu
Neurotransmissors
Aging
Antioxidants
Cytoskeleton
Energy metabolism
Oxidative stress
Neurotransmitters
Issue Date: 1-Feb-2019
Publisher: Elsevier
Abstract: The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions are unknown. In this review, we focus attention on the role of lipids and the importance of the cross-regionally different vulnerabilities in human brain aging. In particular, we first consider a brief approach to the lipidomics of human brain, the relationship between lipids and lipoxidative damage, the role of lipids in human brain aging, and the specific targets of lipoxidative damage in human brain and during aging. It is proposed that the restricted set of modified proteins and the functional categories involved may be considered putative collaborative factors contributing to neuronal aging, and that mitochondrial ATP synthase is a key lipoxidative target in human brain aging.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.redox.2018.101082
It is part of: Journal of Clinical Neuroscience, 2019, vol. 60, p. 124-127
URI: http://hdl.handle.net/2445/140957
Related resource: https://doi.org/10.1016/j.redox.2018.101082
ISSN: 0967-5868
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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