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|Title:||BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis|
Zinna, Valentina M.
Koronowski, Kevin B.
Smith, Jacob G.
Marín Guillén, Inés
Martín Caballero, Juan
Aznar Benitah, Salvador
|Abstract:||Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues.|
|Note:||Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.cell.2019.05.009|
|It is part of:||Cell, 2019, vol. 177, num. 6, p. 1436-1447|
|Appears in Collections:||Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))|
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