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http://hdl.handle.net/2445/141524
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DC Field | Value | Language |
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dc.contributor.advisor | Reguera, D. (David) | - |
dc.contributor.author | Garrido Zornoza, Miguel | - |
dc.date.accessioned | 2019-10-02T13:27:28Z | - |
dc.date.available | 2019-10-02T13:27:28Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/141524 | - |
dc.description | Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2019, Tutor: David Reguera López | ca |
dc.description.abstract | The morphogenesis of a virus is one of the most important steps in its life cycle, since a well-formed structure is vital to survive in hostile environments and to infect hosts. Viral selfassembly resembles a nucleation process where individual proteins stochastically form aggregates driven by a favourable free-energy of binding. The kinetics of the process is strongly regulated by the existence of a free-energy barrier between the viral constituents in solution and the fully-formed virus, in analogy with a first-order phase transition. In this work a coarse-grained model of viral assembly units is implemented in a Brownian Dynamics simulation and used to characterize viral nucleation kinetics. From simulations we evaluate the steady-state rate of capsid formation and reconstruct the free-energy landscape of the process, from which the critical capsid size and the nucleation barrier are obtained. Finally, a brief comparison of the simulations results with the predictions of classical nucleation theory (CNT) is discussed | ca |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.rights | cc-by-nc-nd (c) Garrido, 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Treballs Finals de Grau (TFG) - Física | - |
dc.subject.classification | Càpsida | cat |
dc.subject.classification | Nucleació | cat |
dc.subject.classification | Treballs de fi de grau | cat |
dc.subject.other | Capsid | eng |
dc.subject.other | Nucleation | eng |
dc.subject.other | Bachelor's theses | eng |
dc.title | Coarse-Grained Simulations of the Assembly of Empty Viral Capsids | eng |
dc.type | info:eu-repo/semantics/bachelorThesis | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
Appears in Collections: | Treballs Finals de Grau (TFG) - Física |
Files in This Item:
File | Description | Size | Format | |
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GARRIDO ZORNOZA Miguel.pdf | 1.28 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License