Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/141637
Title: Development of a population pharmacokinetic model for Busulfan in hematopoietic stem cell transplantation
Author: Reina Aibar, Marc
Director/Tutor: Colom Codina, Helena
Keywords: Treballs de fi de grau
Fisiologia cel·lular
Càncer
Farmacocinètica
Cell physiology
Cancer
Pharmacokinetics
Bachelor's thesis
Issue Date: Jun-2019
Abstract: The applications of Busulfan as a chemotherapeutic agent has been disappearing over the years as better therapeutic alternatives have been released. Nowadays it is mainly used for some myeloproliferative diseases and the conditioning process previous to Hematopoietic Stem Cell Transplantation. During this project, data was collected from 98 patients taking Busulfan for the aforementioned conditioning, which were further used to develop a population pharmacokinetic model aiming to predict plasma concentrations of the drug in patients. A one-compartment model best described the data, which adjusted its interindividual variability for clearance (CL/F) with a Typical Value of 11.0 L/h, and for the distribution volume (V/F) with a Typical Value of 42.7 L. Both parameters showed a better fit to the data by the application of the Adjusted Ideal Body Weight covariate to explain the residual error. The final model went through two internal validation processes and will be used henceforth in the clinical pharmacokinetic unit of the Catalan Oncology Institute targeting those patients with potential to achieve toxic concentrations and avoid adverse events derived from its use.
Note: Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 2019. Tutor/a: Helena Colom Codina
URI: http://hdl.handle.net/2445/141637
Appears in Collections:Treballs Finals de Grau (TFG) - Farmàcia

Files in This Item:
File Description SizeFormat 
TFG Reina_Aibar_TFG.pdf1.24 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons