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http://hdl.handle.net/2445/141842
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DC Field | Value | Language |
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dc.contributor.author | Patrick, Sarah | - |
dc.contributor.author | Corrigan, Rachel | - |
dc.contributor.author | Grizzanti, Johna | - |
dc.contributor.author | Mey, Megan | - |
dc.contributor.author | Blair, Jeff | - |
dc.contributor.author | Pallàs i Llibería, Mercè, 1964- | - |
dc.contributor.author | Camins Espuny, Antoni | - |
dc.contributor.author | Lee, Hyoung-gon | - |
dc.contributor.author | Casadesús, Gemma | - |
dc.date.accessioned | 2019-10-08T10:24:59Z | - |
dc.date.available | 2019-10-08T10:24:59Z | - |
dc.date.issued | 2019-04-16 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | http://hdl.handle.net/2445/141842 | - |
dc.description.abstract | Administration of the recombinant analog of the pancreatic amyloid amylin, Pramlintide, has shown therapeutic benefits in aging and Alzheimer's disease (AD) models, both on cognition and amyloid-beta (Aβ) pathology. However, the neuroprotective mechanisms underlying Pramlintide benefits remain unclear. Given the early and critical role of oxidative stress in AD pathogenesis and the known ROS modulating function of amyloids we sought to determine whether Pramlintide's neuroprotective effects involve regulation of oxidative stress mechanisms. To address this we treated APP/PS1 transgenic mice with Pramlintide for 3 months, starting at 5.5 months prior to widespread AD pathology onset, and measured cognition (Morris Water Maze), AD pathology, and oxidative stress-related markers and enzymes in vivo. In vitro, we determined the ability of Pramlintide to modulate H2O2-induced oxidative stress levels. Our data show that Pramlintide improved cognitive function, altered amyloid-processing enzymes, reduced plaque burden in the hippocampus, and regulated endogenous antioxidant enzymes (MnSOD and GPx1) and the stress marker HO-1 in a location specific manner. In vitro, Pramlintide treatment in neuronal models reduced H2O2-induced endogenous ROS production and lipid peroxidation in a dose-dependent manner. Together, these results indicate that Pramlintide's benefits on cognitive function and pathology may involve antioxidant-like properties of this compoun | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | IOS Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3233/JAD-180421 | - |
dc.relation.ispartof | Journal of Alzheimer's Disease, 2019, vol. 69, num. 1, p. 157.-168 | - |
dc.relation.uri | https://doi.org/10.3233/JAD-180421 | - |
dc.rights | (c) Patrick, Sarah et al., 2019 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.classification | Estrès oxidatiu | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Envelliment | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | Oxidative stress | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Aging | - |
dc.title | Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 691033 | - |
dc.date.updated | 2019-10-08T10:25:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30958347 | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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691033.pdf | 1.13 MB | Adobe PDF | View/Open |
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