Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/141941
Title: Lipid raft aging in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzehimer's disease
Author: Díaz, Mario
Fabelo, Noemí
Ferrer, Isidro (Ferrer Abizanda)
Marín, Raquel
Keywords: Envelliment
Metabolisme
Malaltia d'Alzheimer
Etiologia
Escorça cerebral
Aging
Metabolism
Alzheimer's disease
Etiology
Cerebral cortex
Issue Date: 1-Jul-2018
Publisher: Elsevier B.V.
Abstract: Lipid rafts are highly dynamic membrane domains featured by distinctive biochemical composition and physicochemical properties compared with the surrounding plasma membrane. These microstructures are associated not only with cellular signaling and communication in normal nerve cells but also with pathological processing of amyloid precursor protein in Alzheimer's disease. Using lipid rafts isolated from human frontal cortex in nondemented subjects aging 24 to 85 years, we demonstrate here that lipid structure of lipid rafts undergo significant alterations of specific lipid classes and phospholipid-bound fatty acids as brain cortex correlating with aging. Main changes affect levels of plasmalogens, polyunsaturated fatty acids (especially docosahexaenoic acid and arachidonic acid), total polar lipids (mainly phosphatidylinositol, sphingomyelin, sulfatides, and cerebrosides), and total neutral lipids (particularly cholesterol and sterol esters). Besides, relevant relationships between main fatty acids and/or lipid classes were altered in an age-related manner. This 'lipid raft aging' exhibits clear gender differences and appear to be more pronounced in women than in men, especially in older (postmenopausal) women. The outcomes led us to conclude that human cortical lipid rafts are modified by aging in a gender-dependent fashion. Given the central role of bilayer lipid matrix in lipid rafts functionality and neuronal signaling, we hypothesize that these findings might underlie the higher prevalence of cognitive decline evolving toward Alzheimer's disease in postmenopausal women.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2018.02.022
It is part of: Neurobiology of Aging, 2018, vol. 67, p. 42-52
URI: http://hdl.handle.net/2445/141941
Related resource: https://doi.org/10.1016/j.neurobiolaging.2018.02.022
ISSN: 0197-4580
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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