Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/141947
Title: Fibre-type-specific and Mitochondrial Biomarkers of Muscle Damage after Mountain Races
Author: Carmona Dalmases, Gerard
Roca, Emma
Guerrero, Mario
Cussó Fresquet, M. Roser
Bárcena, Cristina
Mateu, Mercè
Cadefau Surroca, Joan Aureli
Keywords: Marcadors bioquímics
Exercici
Fisiologia de l'exercici
Cèl·lules musculars
Biochemical markers
Exercise
Exercise physiology
Muscle cells
Issue Date: 5-Mar-2019
Publisher: Georg Thieme Verlag
Abstract: Consequences of running mountain races on muscle damage were investigated by analysing serum muscle enzymes and fibre-type-specific sarcomere proteins. We studied 10 trained amateur and 6 highly trained runners who ran a 35 km and 55 km mountain trail race (MTR), respectively. Levels of creatine kinase (CK), CK-MB isoform (CK-MB), sarcomeric mitochondrial CK (sMtCK), transaminases (AST and ALT), cardiac troponin I (cTnI) and fast (FM) and slow myosin (SM) isoforms, were assessed before, 1 h, 24 h and 48 h after the beginning of MTR. Significant SM increases were found at 24 h in the 55 km group. Levels of CK, CK-MB, AST and cTnI were significantly elevated in both groups following MTR, but in the 55 km group they tended to stabilize in at 48 h. Using pooled data, time-independent serum peaks of SM and CK-MB were significantly correlated. Moreover, concentration of sMtCK was significantly elevated at 1 and 24 h after the race in the 35 km group. Although training volume could confer protection on the mitochondria, the increase in serum CK-MB and SM in the 55 km group might be related to damage to the contractile apparatus type I fibres. Competing in long-distance MTRs might be related to deeper type I muscle fibre damage, even in highly trained individuals.
Note: Reproducció del document publicat a: https://doi.org/10.1055/a-0808-4692
It is part of: International Journal of Sports Medicine, 2019, vol. 40, num. 4, p. 253-262
URI: http://hdl.handle.net/2445/141947
Related resource: https://doi.org/10.1055/a-0808-4692
ISSN: 0172-4622
Appears in Collections:Articles publicats en revistes (Biomedicina)

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