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Title: Role of tau N-terminal motif in the secretion of human tau by end binding proteins
Author: Sayas, C. Laura
Medina, Miguel
Cuadros, Raquel
Ollá, Ivanna
García, Esther
Pérez, Mar
Ferrer, Isidro (Ferrer Abizanda)
Hernández, Félix
Avila, Jesús
Keywords: Fixació de proteïnes
Protein binding
Issue Date: 22-Jan-2019
Publisher: Public Library of Science (PLoS)
Abstract: For unknown reasons, humans appear to be particular susceptible to developing tau pathology leading to neurodegeneration. Transgenic mice are still undoubtedly the most popular and extensively used animal models for studying Alzheimer's disease and other tauopathies. While these murine models generally overexpress human tau in the mouse brain or specific brain regions, there are differences between endogenous mouse tau and human tau protein. Among them, a main difference between human and mouse tau is the presence of a short motif spanning residues 18 to 28 in the human tau protein that is missing in murine tau, and which could be at least partially responsible for that different susceptibility across species. Here we report novel data using affinity chromatography analysis indicating that the sequence containing human tau residues 18 to 28 acts a binding motif for End Binding proteins and that this interaction could facilitate tau secretion to the extracellular space.
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It is part of: PLoS One, 2019, vol. 14, num. 1, p. e0210864
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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