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Title: Serum 25-hydroxyvitamin D and breast cancer risk by pathological subtype (MCC-Spain)
Author: Lope, Virginia
Castelló, Adela
Mena Bravo, Antonio
Amiano, Pilar
Aragonés, Nuria
Fernández Villa, Tania
Guevara, Marcela
Dierssen Sotos, Trinidad
Fernandez Tardón, Guillermo
Castaño Vinyals, Gemma
Marcos Gragera, Rafael
Moreno Aguado, Víctor
Salas Trejo, Dolores
Diaz Santos, Marian
Oribe, Madalen
Romieu, Isabel
Kogevinas, Manolis
Priego Capote, Feliciano
Pérez Gómez, Beatriz
Pollán, Marina
Keywords: Càncer de mama
Vitamina D
Breast cancer
Vitamin D
Issue Date: 1-Sep-2018
Publisher: Elsevier Ltd
Abstract: Epidemiologic evidence on the association between vitamin D and breast cancer is still inconclusive. This study analyzes the association between serum 25-hydroxyvitamin D (25(OH)D) and breast cancer risk by pathologic subtype, stage at diagnosis and specific breast cancer risk factors. We conducted a population-based multicase-control study where 546 histologically-confirmed breast cancer cases and 558 population controls, frequently matched by geographic area, age and body mass index, were recruited in 12 Spanish provinces (MCC-Spain). Information was collected by a questionnaire and plasma 25(OH)D was measured by solid-phase extraction on-line coupled to liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS). Odds ratios and 95% confidence intervals were calculated using logistic and multinomial mixed regression models. We found a clear protective effect between 25(OH)D levels and breast cancer risk, with a significant dose-response trend (OR per 10 nmol/L = 0.88; 95%CI = 0.82-0.94). While no differences were observed between pre and postmenopausal women, stage at diagnosis, or across strata of the main breast cancer risk factors, the protection was more pronounced for triple negative tumors (OR per 10 nmol/L = 0.64; p-heterogeneity = 0.038). Similar results were observed when only cases sampled in the first month after diagnosis were considered. The protective effect of vitamin D on breast cancer risk may be subtype specific, being stronger for more aggressive tumors, which provides a new approach to prevent this disease.
Note: Versió postprint del document publicat a:
It is part of: Journal of Steroid Biochemistry and Molecular Biology, 2018, vol. 182, p. 4-13
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ISSN: 0960-0760
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (ISGlobal)

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