Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/143362
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DC Field | Value | Language |
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dc.contributor.author | Cabré Montesinos, Albert | - |
dc.contributor.author | Verdaguer i Espaulella, Xavier | - |
dc.contributor.author | Riera i Escalé, Antoni | - |
dc.date.accessioned | 2019-10-28T17:24:41Z | - |
dc.date.available | 2020-08-05T05:10:28Z | - |
dc.date.issued | 2019-08-05 | - |
dc.identifier.issn | 1615-4150 | - |
dc.identifier.uri | http://hdl.handle.net/2445/143362 | - |
dc.description.abstract | The iridium-catalyzed asym. hydrogenation of several N-sulfonyl allyl amines was reported. All substrates could be easily obtained by the Ir-catalyzed isomerization of N-tosylaziridines reported previously. The com. available threonine-derived phosphinite (UbaPHOX) iridium complex had been found to be the best catalyst for this catalytic application, affording β-Me amines I [R1 = H, 4-Cl, 4-Br, etc.;R2 = Me, i-Pr, 4-MeC6H4; R3 = H, Me] with good to excellent ee values (up to 94%). The synthetic potential of this novel methodol. was demonstrated by the formal synthesis of Lorcaserin and LY-404187. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/adsc.201900748 | - |
dc.relation.ispartof | Advanced Synthesis & Catalysis, 2019, vol. 361, num. 18, p. 4196-4200 | - |
dc.relation.uri | https://doi.org/10.1002/adsc.201900748 | - |
dc.rights | (c) Wiley-VCH, 2019 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Iridi | - |
dc.subject.classification | Catàlisi asimètrica | - |
dc.subject.classification | Hidrogenació | - |
dc.subject.classification | Síntesi de fàrmacs | - |
dc.subject.other | Iridium | - |
dc.subject.other | Enantioselective catalysis | - |
dc.subject.other | Hydrogenation | - |
dc.subject.other | Drug synthesis | - |
dc.title | Enantioselective Synthesis of β-Methyl Amines via Iridium-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Allyl Amines. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 692337 | - |
dc.date.updated | 2019-10-28T17:24:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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692337.pdf | 406.38 kB | Adobe PDF | View/Open |
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