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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/143378
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dc.contributor.authorPallicer Santana, Juan Manuel-
dc.contributor.authorRosés Pascual, Martí-
dc.contributor.authorRàfols Llach, Clara-
dc.contributor.authorBosch, Elisabeth-
dc.contributor.authorPascual, Rosalía-
dc.contributor.authorPort, Ariadna-
dc.date.accessioned2019-10-28T17:49:39Z-
dc.date.available2019-10-28T17:49:39Z-
dc.date.issued2014-
dc.identifier.issn1848-7718-
dc.identifier.urihttp://hdl.handle.net/2445/143378-
dc.description.abstractThe iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187.-
dc.format.extent8 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherIAPC Publishing-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.5599/admet.2.2.45-
dc.relation.ispartofADMET & DMPK, 2014, vol. 2, num. 2, p. 107-114-
dc.relation.urihttps://doi.org/10.5599/admet.2.2.45-
dc.rightscc-by (c) Pallicer Santana, Juan Manuel et al., 2014-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)-
dc.subject.classificationLipofília-
dc.subject.classificationQuímica farmacèutica-
dc.subject.otherLipophilicity-
dc.subject.otherPharmaceutical chemistry-
dc.titleEvaluation of logPo/w values of drugs from some molecular structure calculation software-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec643435-
dc.date.updated2019-10-28T17:49:39Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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