Please use this identifier to cite or link to this item:
Title: Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
Author: Garcia Esparcia, Paula
Sideris-Lampretsas, Georgios
Hernández Ortega, Karina
Grau-Rivera, Oriol
Sklaviadis, Theodoros
Gelpi, Ellen
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Ratolins transgènics
Malaltia d'Alzheimer
Síntesi proteica
Transgenic mice
Alzheimer's disease
Protein synthesis
Issue Date: 15-Jun-2017
Publisher: e-Century Publishing
Abstract: Expression of the nucleolar chaperones nucleolin (NCL) and nucleophosmin (NPM1), upstream binding transcription factor (UBTF), rRNA18S, rRNA28S, and several genes encoding ribosomal proteins (RPs) is decreased in frontal cortex area 8 at advanced stages of Alzheimer's disease (AD). This is accompanied by reduced protein levels of elongation factors eEF1A and eEF2. Changes are more marked in AD cases with rapid course (rpAD), as initiation factor eIF3η is significantly down-regulated and several RP genes up-regulated in rpAD when compared with typical AD. These changes contrast with those seen in APP/PS1 transgenic mice used as a model of AD-like β-amyloidopathy; Ncl mRNA, rRNA18S, rRNA28S and seven out of fifteen assessed RP genes are up-regulated in APP/PS1 mice aged 20 months; only eEF2 protein levels are reduced in transgenic mice. Our findings show marked altered expression of molecules linked to the protein synthesis machinery from the nucleolus to the ribosome in frontal cortex at terminal stages of AD which differs from that seen in APP/PS1 transgenic mice, thus further suggesting that molecular signals in mouse models do not apply to real human disease counterparts.
Note: Reproducció del document publicat a:
It is part of: American Journal Neurodegenerative Diseases , 2017, vol. 6, num. 2, p. 15-25
ISSN: 2165-591X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Patologia i Terapèutica Experimental)

Files in This Item:
File Description SizeFormat 
690400.pdf1.12 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons