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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/143718
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dc.contributor.authorManzine, Patricia-
dc.contributor.authorEttcheto Arriola, Miren-
dc.contributor.authorCano Fernández, Amanda-
dc.contributor.authorBusquets Figueras, Oriol-
dc.contributor.authorMarcello, Elena-
dc.contributor.authorPelucchi, Silvia-
dc.contributor.authorDi Luca, Monica-
dc.contributor.authorEndres, Kristina-
dc.contributor.authorOlloquequi, Jordi-
dc.contributor.authorCamins Espuny, Antoni-
dc.contributor.authorCominetti, Márcia Regina-
dc.date.accessioned2019-11-04T10:33:38Z-
dc.date.available2019-11-04T10:33:38Z-
dc.date.issued2019-04-03-
dc.identifier.issn0753-3322-
dc.identifier.urihttp://hdl.handle.net/2445/143718-
dc.description.abstractAlzheimer's disease (AD) represents a global burden in the economics of healthcare systems. Amyloid-β (Aβ) peptides are formed by amyloid-β precursor protein (AβPP) cleavage, which can be processed by two pathways. The cleavage by the α-secretase A Disintegrin And Metalloprotease 10 (ADAM10) releases the soluble portion (sAβPPα) and prevents senile plaques. This pathway remains largely unknown and ignored, mainly regarding pharmacological approaches that may act via different signaling cascades and thus stimulate non-amyloidogenic cleavage through ADAM10. This review emphasizes the effects of natural compounds on ADAM10 modulation, which eventuates in a neuroprotective mechanism. Moreover, ADAM10 as an AD biomarker is revised. New treatments and preventive interventions targeting ADAM10 regulation for AD are necessary, considering the wide variety of ADAM10 substrates.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier Masson SAS-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.biopha.2019.108661-
dc.relation.ispartofBiomedicine & Pharmacotherapy, 2019-
dc.relation.urihttps://doi.org/10.1016/j.biopha.2019.108661-
dc.rights(c) Elsevier Masson SAS, 2019-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationMalaltia d'Alzheimer-
dc.subject.classificationProteïnes-
dc.subject.classificationFarmacologia-
dc.subject.otherAlzheimer's disease-
dc.subject.otherProteins-
dc.subject.otherPharmacology-
dc.titleADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec691035-
dc.date.updated2019-11-04T10:33:39Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid30836275-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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