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Title: Targeting autophagy for cancer treatment and tumor chemosensitization
Author: Pérez-Hernández, Marta
Arias, Alain
Martínez García, David
Pérez Tomás, Ricardo E.
Quesada, Roberto
Soto Cerrato, Vanessa
Keywords: Mort cel·lular
Quimioteràpia del càncer
Cell death
Cancer chemotherapy
Issue Date: 19-Oct-2019
Publisher: MDPI
Abstract: Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from damaged organelles and other cellular components through lysosomal degradation. Deregulation of this process has been associated with the development of several pathophysiological processes, such as cancer and neurodegenerative diseases. In cancer, autophagy has opposing roles, being either cytoprotective or cytotoxic. Thus, deciphering the role of autophagy in each tumor context is crucial. Moreover, autophagy has been shown to contribute to chemoresistance in some patients. In this regard, autophagy modulation has recently emerged as a promising therapeutic strategy for the treatment and chemosensitization of tumors, and has already demonstrated positive clinical results in patients. In this review, the dual role of autophagy during carcinogenesis is discussed and current therapeutic strategies aimed at targeting autophagy for the treatment of cancer, both under preclinical and clinical development, are presented. The use of autophagy modulators in combination therapies, in order to overcome drug resistance during cancer treatment, is also discussed as well as the potential challenges and limitations for the use of these novel therapeutic strategies in the clinic.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2019, vol. 11, num. 10, p. 1599
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ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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