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Title: Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
Author: Cillóniz, Catia
Dominedò, Cristina
Ielpo, Antonella
Ferrer Monreal, Miquel
Gabarrús, Albert
Battaglini, Denise
Bermejo Martín, Jesús
Meli, Andrea
Garcia Vidal, Carolina
Liapikou, Adamantia
Singer, Mervyn
Torres Martí, Antoni
Keywords: Pneumònia adquirida a la comunitat
Persones grans
Community-acquired pneumonia
Older people
Issue Date: 2-Jul-2019
Publisher: MDPI
Abstract: Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.
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It is part of: Journal of Clinical Medicine, 2019, vol. 8, num. 7
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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