Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/146044
Title: | Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial |
Author: | Cantero, Irene Abete, Itziar Babio, Nancy Arós, Fernando Corella Piquer, Dolores Estruch Riba, Ramon Fitó Colomer, Montserrat Hébert, James R. Martínez-González, Miguel Ángel, 1957- Pintó Sala, Xavier Portillo, María P. Ruiz Canela, Miguel Shivappa, Nitin Wärnberg, Julia Gómez Gracia, Enrique Tur, Josep Antoni Salas Salvadó, Jordi Zulet, M. Angeles Martínez, J. Alfredo, 1957- |
Keywords: | Malalties del fetge Teixit adipós Liver diseases Adipose tissues |
Issue Date: | Oct-2018 |
Publisher: | Elsevier |
Abstract: | BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-α and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. RESULTS: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. CONCLUSIONS: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.clnu.2017.06.027 |
It is part of: | Clinical Nutrition, 2018, vol. 37, num. 5, p. 1736-1743 |
URI: | http://hdl.handle.net/2445/146044 |
Related resource: | https://doi.org/10.1016/j.clnu.2017.06.027 |
ISSN: | 0261-5614 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
688106.pdf | 1.49 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License