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http://hdl.handle.net/2445/147097
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DC Field | Value | Language |
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dc.contributor.author | Molleví, David G. | - |
dc.contributor.author | Aytés Meneses, Álvaro | - |
dc.contributor.author | Padullés Mosella, Laura | - |
dc.contributor.author | Martínez Iniesta, María | - |
dc.contributor.author | Baixeras, Núria | - |
dc.contributor.author | Salazar Soler, Ramón | - |
dc.contributor.author | Ramos Rubio, Emilio | - |
dc.contributor.author | Figueras Aloy, José, 1950- | - |
dc.contributor.author | Capellá, G. (Gabriel) | - |
dc.contributor.author | Villanueva Garatachea, Alberto | - |
dc.date.accessioned | 2019-12-20T15:50:20Z | - |
dc.date.available | 2019-12-20T15:50:20Z | - |
dc.date.issued | 2008-10-28 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.uri | http://hdl.handle.net/2445/147097 | - |
dc.description.abstract | Phosphatase PRL-3 has been involved in different types of cancer, especially in metastases from colorectal carcinoma (CRC). In this study, we explored both isoforms of PRL-3 as a biomarker to predict the recurrence of stage IIIB-C CRC. Overexpression of PRL-3 was investigated in primary human colorectal tumours (n=20) and hepatic metastases (n=36) xenografted in nude mice, samples characterised by absence of human non-tumoral cells, showing a high degree of expression in metastases (P=0.001). In 27 cases of matched normal colonic mucosa/primary tumour/hepatic metastases, PRL-3 overexpression occurs in primary tumours vs normal mucosa (P=0.001) and in hepatic metastases vs primary tumours (P=0.045). Besides, our results in a series of 80 stage IIIB-C CRC primary tumours showed that high levels of PRL-3 were an independent predictor of metastasis (P<0.0001; OR: 9.791) in multivariate analysis of a binary logistic regression and that PRL-3 expression tightly correlates with parameters of bad outcome. Moreover, PRL-3 expression associated with poor outcome in univariate (P<0.0001) and multivariate Cox models (hazard ratio: 3.322, 95%, confidence interval: 1.405-7.852, P=0.006). In conclusion, PRL-3 is a good marker of aggressiveness of locally advanced CRS and a promising predictor of distant metastases. Nevertheless, for prognosis purposes, it is imperative to validate the cutoff value of PRL-3 expression in a larger and consecutive series and adjuvant setting. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cancer Research UK | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/sj.bjc.6604747 | - |
dc.relation.ispartof | British Journal of Cancer, 2008, vol. 99, num. 10, p. 1718-1725 | - |
dc.relation.uri | https://doi.org/10.1038/sj.bjc.6604747 | - |
dc.rights | (c) Molleví, David Garcia et al., 2008 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Patologia | - |
dc.subject.classification | Càncer de fetge | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Pathology | - |
dc.subject.other | Liver cancer | - |
dc.title | PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 606220 | - |
dc.date.updated | 2019-12-20T15:50:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 19002188 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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File | Description | Size | Format | |
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606220.pdf | 310.09 kB | Adobe PDF | View/Open |
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