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http://hdl.handle.net/2445/147117| Title: | COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer |
| Author: | Tomlinson, Ian P. Dunlop, Malcolm Campbell, Harry Zanke, Brent W. Gallinger, Steven Hudson, Thomas J. Koessler, Thibaud Pharoah, Paul D. P. Niittymäki, Iina Tuupanen, Sari Aaltonen, Lauri A. Hemminki, Kari Lindblom, Annika Försti, Asta Sieber, Oliver Lipton, Lara Van Wezel, Tom Morreau, Hans Wijnen, Juul Devilee, Peter Matsuda, Kenji Nakamura, Yusuke Castellví Bel, Sergi Ruiz-Ponte, Clara Castells Garangou, Antoni Carracedo Álvarez, Ángel Ho, J.W. Sham, Pak Chung Hofstra, Robert Vodicka, Pavel Brenner, Hermann Hampe, Jochen Schafmayer, Clemens Tepel, Juergen Schreiber, Stefan Völzke, Henry Lerch, Markus M. Schmidt, Christian A. Buch, Stephan Moreno Aguado, Víctor |
| Keywords: | Càncer colorectal Genètica Polimorfisme genètic Colorectal cancer Genetics Genetic polymorphisms |
| Issue Date: | 15-Jul-2010 |
| Publisher: | Cancer Research UK |
| Abstract: | It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1038/sj.bjc.6605338 |
| It is part of: | British Journal of Cancer, 2010, vol. 102, num. 2, p. 447-454 |
| URI: | http://hdl.handle.net/2445/147117 |
| Related resource: | https://doi.org/10.1038/sj.bjc.6605338 |
| ISSN: | 0007-0920 |
| Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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| 593140.pdf | 343.63 kB | Adobe PDF | View/Open |
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