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Title: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
Author: Tomlinson, Ian P.
Dunlop, Malcolm
Campbell, Harry
Zanke, Brent
Gallinger, Steven
Hudson, Thomas J.
Koessler, Thibaud
Pharoah, Paul D. P.
Niittymäki, Iina
Tuupanen, Sari
Aaltonen, Lauri A.
Hemminki, Kari
Lindblom, Annika
Försti, Asta
Sieber, Oliver
Lipton, Lara
Van Wezel, Tom
Morreau, Hans
Wijnen, Juul
Devilee, Peter
Matsuda, Kenji
Nakamura, Yusuke
Castellví Bel, Sergi
Ruiz-Ponte, Clara
Castells Garangou, Antoni
Carracedo Álvarez, Ángel
Ho, J.W.
Sham, Pak Chung
Hofstra, Robert
Vodicka, Pavel
Brenner, Hermann
Hampe, Jochen
Schafmayer, Clemens
Tepel, Juergen
Schreiber, Stefan
Völzke, Henry
Lerch, Markus M.
Schmidt, Christian A.
Buch, Stephan
Moreno Aguado, Víctor
Keywords: Càncer colorectal
Polimorfisme genètic
Colorectal cancer
Genetic polymorphisms
Issue Date: 15-Jul-2010
Publisher: Cancer Research UK
Abstract: It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
Note: Versió postprint del document publicat a:
It is part of: British Journal of Cancer, 2010, vol. 102, num. 2, p. 447-454
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ISSN: 0007-0920
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Ciències Clíniques)

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