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http://hdl.handle.net/2445/147198| Title: | Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC |
| Author: | Pinyol, Roser Sia, Daniela Llovet i Bayer, Josep Maria |
| Keywords: | Marcadors bioquímics Càncer de fetge Biochemical markers Liver cancer |
| Issue Date: | 7-Jan-2019 |
| Publisher: | American Association for Cancer Research |
| Abstract: | Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.See related article by Harding et al.©2019 American Association for Cancer Research. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1158/1078-0432.ccr-18-3778 |
| It is part of: | Clinical Cancer Research, 2019, vol. 25, num. 7, p. 2021-2023 |
| URI: | http://hdl.handle.net/2445/147198 |
| Related resource: | https://doi.org/10.1158/1078-0432.ccr-18-3778 |
| ISSN: | 1078-0432 |
| Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 12474_4217699_ccr_translations_llovet_open_access.pdf | 399.01 kB | Adobe PDF | View/Open |
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