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Title: Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC
Author: Pinyol, Roser
Sia, Daniela
Llovet i Bayer, Josep Maria
Keywords: Marcadors bioquímics
Càncer de fetge
Biochemical markers
Liver cancer
Issue Date: 7-Jan-2019
Publisher: American Association for Cancer Research
Abstract: Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.See related article by Harding et al.©2019 American Association for Cancer Research.
Note: Versió postprint del document publicat a:
It is part of: Clinical Cancer Research, 2019, vol. 25, num. 7, p. 2021-2023
Related resource:
ISSN: 1078-0432
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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