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Title: Antibody-Mediated Encephalitis
Author: Dalmau Obrador, Josep
Graus Ribas, Francesc
Keywords: Encefalitis
Issue Date: 1-Mar-2018
Publisher: NJEM Group
Abstract: Antibody-mediated encephalitides constitute a group of inflammatory brain diseases that are characterized by prominent neuropsychiatric symptoms and are associated with antibodies against neuronal cell-surface proteins, ion channels, or receptors (Table 1).1 Common clinical features include a change in behavior, psychosis, seizures, memory and cognitive deficits, abnormal movements, dysautonomia, and a decreased level of consciousness. There are, however, no systemic manifestations other than autonomic dysfunction, and this group of diseases is separable from traditional autoimmune disorders such as systemic lupus erythematosus, which may affect the nervous system. Also separate from this group of antibody-mediated encephalitides are several disorders, some of which are paraneoplastic, such as cerebellar degeneration,2 neuromyelitis optica,3 and stiff-person spectrum diseases,4 that are associated with antibodies against neuronal or glial cell-surface antigens but that are rarely associated with the aforementioned symptoms. The antibody-mediated encephalitides occur in persons
Note: Reproducció del document publicat a:
It is part of: New England Journal of Medicine, 2018, vol. 378, num. 9, p. 840-851
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ISSN: 0028-4793
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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