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http://hdl.handle.net/2445/147228
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DC Field | Value | Language |
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dc.contributor.author | García, Juan Ignacio | - |
dc.contributor.author | Kelley, Holden V. | - |
dc.contributor.author | Meléndez, Johanna | - |
dc.contributor.author | Alvarez de León, Rosa Alejandra | - |
dc.contributor.author | Castillo, Alejandra | - |
dc.contributor.author | Sidiki, Sabeen | - |
dc.contributor.author | Yusoof, Kizil A. | - |
dc.contributor.author | Nunes, Elizabete | - |
dc.contributor.author | López Téllez, Cesar | - |
dc.contributor.author | Mejía Villatoro, Carlos Rodolfo | - |
dc.contributor.author | Ikeda, Janet | - |
dc.contributor.author | García-Basteiro, Alberto L. | - |
dc.contributor.author | Wang, Shu-Hua | - |
dc.contributor.author | Torrelles, Jordi B. | - |
dc.date.accessioned | 2020-01-08T14:31:21Z | - |
dc.date.available | 2020-01-08T14:31:21Z | - |
dc.date.issued | 2019-11-29 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/147228 | - |
dc.description.abstract | Tuberculosis (TB) disease still kills 1-person every 21-seconds. Few TB diagnostic tests are considered truly appropriate for point of care settings. The WHO-endorsed immunodiagnostic Alere Determine Lipoarabinomannan Ag-test (LAM-test) detects Mycobacterium tuberculosis complex LAM in urine, and its use is recommended for TB diagnosis among HIV co-infected individuals with low CD4 T-cell counts. Here we found that a simple 15-minute enzymatic treatment at room temperature of LAM-spiked urine with \xCE\xB1-mannosidase (for human TB), and LAM-spiked milk with combined lactase and caseinase (for bovine TB), enhanced 10-fold the detection levels of the LAM-test and thus, improved the detection of LAM by the LAM-test in urine and milk that otherwise could be missed in the field. Future separate clinical research studies specifically designed to address the potential of these findings are required. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/s41598-019-54537-9 | - |
dc.relation.ispartof | Scientific Reports, 2019, vol. 9, p. 18012 | - |
dc.relation.uri | http://dx.doi.org/10.1038/s41598-019-54537-9 | - |
dc.rights | cc by (c) García et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Tuberculosi | - |
dc.subject.classification | Diagnòstic immunològic | - |
dc.subject.other | Tuberculosis | - |
dc.subject.other | Immunodiagnosis | - |
dc.title | Improved Alere Determine Lipoarabinomannan Antigen Detection Test for the Diagnosis of Human and Bovine Tuberculosis by Manipulating Urine and Milk | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2019-12-20T19:01:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31784649 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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GarciaJI_SciRep_2019.pdf | 1.44 MB | Adobe PDF | View/Open |
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